Energy deprivation is a frequent adverse event in tumors that is caused by mutations,
malperfusion, hypoxia, and nutrition deficit. The resulting bioenergetic stress leads to …

There is ample evidence that, instead of a binary switch, epithelial-mesenchymal transition
(EMT) in cancer results in a flexible array of phenotypes, each one uniquely suited to a stage …

Cancer invasion and metastasis require remodeling of the adjacent extracellular matrix
(ECM). In this mini review, we will cover the mechanisms of proteolytic degradation and the …

Spontaneous locomotion is a common feature of most metazoan cells, generally attributed to
the fundamental properties of the actomyosin network. This force-producing machinery has …

Skin melanocytes reside on the basement membrane (BM), which is mainly composed of
laminin, collagen type IV, and proteoglycans. For melanoma cells, in order to invade into the …