Modeling perspectives on the intestinal crypt, a canonical system for growth, mechanics, and remodeling

AA Almet, PK Maini, DE Moulton, HM Byrne - Current Opinion in Biomedical …, 2020 - Elsevier
The intestinal epithelium is crucial to maintaining a healthy gut. Central to this are the crypts
of Lieberkühn, which coordinate the rapid self-renewal of the epithelium to protect the small …

Biomathematical model for simulating abnormal orifice patterns in colonic crypts

IN Figueiredo, C Leal, G Romanazzi… - Mathematical …, 2019 - Elsevier
Colonic polyps, which are abnormal growths in the colon, are a major concern in colon
cancer diagnosis and prevention. Medical studies evidence that there is a correlation …

Density-pressure IBVP: Numerical analysis, simulation and cell dynamics in a colonic crypt

GCM Campos, JA Ferreira, G Romanazzi - Applied Mathematics and …, 2022 - Elsevier
This paper proposes a finite difference method for a differential-algebraic system that
couples an elliptic equation with a convection-diffusion-reaction equation with mixed …

[HTML][HTML] Mathematical model for simulation of morphological changes associated to crypt fission in the colon

G Romanazzi, G Settanni - Discrete and Continuous Dynamical …, 2022 - aimsciences.org
Morphological changes due to colorectal cancer propagation by an abnormal crypt fission is
an interesting application arising in medicine and biology, that we try to analyse by a …

Modeling and Computer Simulation of Viscoelastic Crypt Deformation

EP Oliveira, G Romanazzi - Trends in Computational and Applied …, 2022 - SciELO Brasil
Colorectal cancer morphogenesis begins at the cellular level from cell mutations in the
intestinal epithelium cavities called crypts. These mutations lead to a pressure difference in …

Biomechanics of intestinal crypt morphogenesis

A Almet - 2019 - ora.ox.ac.uk
The intestinal epithelium exhibits remarkable rates of self-renewal to protect the small
intestine and colon from damage during digestion and facilitate nutrient absorption. This …

Numerical simulation and modelling of crypt fission and tissue deformation in the colon epithelium

G Romanazzi - matematica.ufpr.br
The colon epithelium is filled in its internal walls by small cavities called crypts. These crypts
are small tubular glands, containing proliferative cells, that obey to a programmed cell …

[PDF][PDF] Biomechanical Model for the Simulation of Colonic Pit Patterns

IN Figueiredo, C Leal, G Romanazzi, PN Figueiredo… - math.tecnico.ulisboa.pt
The colonic epithelium is formed by thousands of small cavities, called crypts and the
extremely tiny pits, in the mucosa of the colon, are the crypt orifices. In normal crypts, the pits …

[PDF][PDF] A computational approach to design a restenosis criterion

P de Oliveira - Workshop on, 2017 - math.tecnico.ulisboa.pt
Abstract The use of Drug Eluting Stents (DES) has been an important advancement in the
treatment of in-stent restenosis. However despite all the progress made in DES procedures …

Congress on Numerical Methods in Engineering

JM Blanco, I Arias, MT Valiente - 2015 - dem.ist.utl.pt
ENCURVADURA DE BARRAS DE PAREDE FINA COM SECÇÃO FECHADA SUJEITAS A
CARREGAMENTO ARBITRÁRIO: APLICAÇÃO DA TEORIA GENERALIZAD Page 1 Congress on …