Molecular mechanisms behind the biological effects of hesperidin and hesperetin for the prevention of cancer and cardiovascular diseases

A Roohbakhsh, H Parhiz, F Soltani, R Rezaee… - Life sciences, 2015 - Elsevier
Hesperidin (Hsd) and its aglycone, hesperetin (Hst), are two flavonoids from citrus species
that have various biological properties, particularly those for the prevention of cancer and …

Biosynthesis of citrus flavonoids and their health effects

C Zhao, F Wang, Y Lian, H **ao… - Critical reviews in food …, 2020 - Taylor & Francis
Citrus-derived flavonoids play important roles in the regulation of physiological conditions of
citrus plants, including color changes of flower and fruit, flavor development, and anti-stress …

Chemical structures, bioactivities and molecular mechanisms of citrus polymethoxyflavones

Z Gao, W Gao, SL Zeng, P Li, EH Liu - Journal of Functional Foods, 2018 - Elsevier
Citrus polymethoxyflavones (PMFs) and hydroxylated PMFs demonstrate potent bioactivities
in regulating cytoactivity and organ function by modulating signaling cascade, gene …

Limonin: a review of its pharmacology, toxicity, and pharmacokinetics

S Fan, C Zhang, T Luo, J Wang, Y Tang, Z Chen, L Yu - Molecules, 2019 - mdpi.com
Limonin is a natural tetracyclic triterpenoid compound, which widely exists in Euodia
rutaecarpa (Juss.) Benth., Phellodendron chinense Schneid., and Coptis chinensis Franch …

Orange fruit (Citrus sinensis) peel extract attenuates chemotherapy-induced toxicity in male rats

EA Abdelghffar, HAS El-Nashar, AGA Al-Mohammadi… - Food & function, 2021 - pubs.rsc.org
Background: Cyclophosphamide (CYP) is a chemotherapy drug widely used in the treatment
of several types of cancers and autoimmune disorders. Unfortunately, it causes severe side …

The chemistry and pharmacology of citrus limonoids

R Gualdani, MM Cavalluzzi, G Lentini, S Habtemariam - Molecules, 2016 - mdpi.com
Citrus limonoids (CLs) are a group of highly oxygenated terpenoid secondary metabolites
found mostly in the seeds, fruits and peel tissues of citrus fruits such as lemons, limes …

Recent advances in the biosynthesis, bioavailability, toxicology, pharmacology, and controlled release of citrus neohesperidin

S Akhter, MSI Arman, MA Tayab… - Critical Reviews in …, 2024 - Taylor & Francis
Abstract Neohesperidin (hesperetin 7-O-neohesperidoside), a well-known flavanone
glycoside widely found in citrus fruits, exhibits a variety of biological activities, with potential …

Therapeutic potential of hesperidin and its aglycone hesperetin: Cell cycle regulation and apoptosis induction in cancer models

JMPF de Oliveira, C Santos, E Fernandes - Phytomedicine, 2020 - Elsevier
Background The ability of cancer cells to divide without restriction and to escape
programmed cell death is a feature of the proliferative state. Citrus flavanones are flavonoids …

Variety and ripening impact on phenolic composition and antioxidant activity of mandarin (Citrus reticulate Blanco) and bitter orange (Citrus aurantium L.) seeds …

I Moulehi, S Bourgou, I Ourghemmi… - Industrial Crops and …, 2012 - Elsevier
Changes of antioxidants in the seeds of mandarin (Citrus reticulata) and bitter orange (Citrus
aurantium) fruits during three stages of ripening (IM, SM and CM) were evaluated …

Isolation and biological activities of decanal, linalool, valencene, and octanal from sweet orange oil

K Liu, Q Chen, Y Liu, X Zhou… - Journal of Food Science, 2012 - Wiley Online Library
Product 1 (82.25% valencene), product 2 (73.36% decanal), product 3 (78.12% octanal),
and product 4 (90.61% linalool) were isolated from sweet orange oil by combined usage of …