Therapeutic potential and mechanisms of mesenchymal stem cell-derived exosomes as bioactive materials in tendon–bone healing

J Zou, W Yang, W Cui, C Li, C Ma, X Ji, J Hong… - Journal of …, 2023 - Springer
Tendon–bone insertion (TBI) injuries, such as anterior cruciate ligament injury and rotator
cuff injury, are the most common soft tissue injuries. In most situations, surgical …

Macrophages in cardiovascular diseases: molecular mechanisms and therapeutic targets

R Chen, H Zhang, B Tang, Y Luo, Y Yang… - Signal transduction and …, 2024 - nature.com
The immune response holds a pivotal role in cardiovascular disease development. As
multifunctional cells of the innate immune system, macrophages play an essential role in …

The pros and cons of mesenchymal stem cell-based therapies

A Musiał-Wysocka, M Kot, M Majka - Cell transplantation, 2019 - journals.sagepub.com
The need to search for new, alternative treatments for various diseases has prompted
scientists and physicians to focus their attention on regenerative medicine and broadly …

Adverse events, side effects and complications in mesenchymal stromal cell-based therapies

DS Baranovskii, ID Klabukov… - Stem Cell …, 2022 - pmc.ncbi.nlm.nih.gov
Numerous clinical studies have shown a wide clinical potential of mesenchymal stromal
cells (MSCs) application. However, recent experience has accumulated numerous reports of …

Human mesenchymal stem cells-current trends and future prospective

I Ullah, RB Subbarao, GJ Rho - Bioscience reports, 2015 - portlandpress.com
Stem cells are cells specialized cell, capable of renewing themselves through cell division
and can differentiate into multi-lineage cells. These cells are categorized as embryonic stem …

Manufacturing of primed mesenchymal stromal cells for therapy

JQ Yin, J Zhu, JA Ankrum - Nature biomedical engineering, 2019 - nature.com
Mesenchymal stromal cells (MSCs) for basic research and clinical applications are
manufactured and developed as unique cell products by many different manufacturers and …

Mesenchymal stromal cell therapeutic delivery: translational challenges to clinical application

H Caplan, SD Olson, A Kumar, M George… - Frontiers in …, 2019 - frontiersin.org
For several decades, multipotent mesenchymal stromal cells (MSCs) have been extensively
studied for their therapeutic potential across a wide range of diseases. In the preclinical …

Mesenchymal stem cells in fibrotic disease

E El Agha, R Kramann, RK Schneider, X Li, W Seeger… - Cell stem cell, 2017 - cell.com
Fibrosis is associated with organ failure and high mortality and is commonly characterized
by aberrant myofibroblast accumulation. Investigating the cellular origin of myofibroblasts in …

Recent progress of stem cell therapy in cancer treatment: molecular mechanisms and potential applications

DT Chu, TT Nguyen, NLB Tien, DK Tran, JH Jeong… - Cells, 2020 - mdpi.com
The insufficient and unspecific target of traditional therapeutic approaches in cancer
treatment often leads to therapy resistance and cancer recurrence. Over the past decades …

[HTML][HTML] Stem cell membrane-coated abiotic nanomaterials for biomedical applications

I Ferreira-Faria, S Yousefiasl, A Macário-Soares… - Journal of controlled …, 2022 - Elsevier
Nanoscale materials have been extensively employed for diagnostic and therapeutic
purposes. However, the developed nanosystems still suffer from some limitations, namely …