Across complex, multi-time and-length scale biological systems, redundancy confers
robustness and resilience, enabling adaptation and increasing survival under dynamic …

In addition to biochemical signals and genetic considerations, mechanical forces are rapidly
emerging as a master regulator of human physiology. However, the molecular mechanisms …

Understanding cellular force transmission dynamics is crucial in mechanobiology. We
developed the DNA-based ForceChrono probe to measure force magnitude, duration, and …

The talin-vinculin axis is a key mechanosensing component of cellular focal adhesions. How
talin and vinculin respond to forces and regulate one another remains unclear. By …

T cells defend against cancer and viral infections by rapidly scanning the surface of target
cells seeking specific peptide antigens. This key process in adaptive immunity is sparked …

Talins are cytoskeletal linker proteins that consist of an N-terminal head domain, a flexible
neck region and a C-terminal rod domain made of 13 helical bundles. The head domain …

Viscoelasticity and its alteration in time and space has turned out to act as a key element in
fundamental biological processes in living systems, such as morphogenesis and motility …

Mechanotransduction, the process by which cells respond to tension transmitted through
various supramolecular linkages, is important for understanding cellular behavior. Tension …

Force transmission through adherens junctions (AJs) is crucial for multicellular organization,
wound healing and tissue regeneration. Recent studies shed light on the molecular …

Biopolymers that mimic the extracellular matrix are favourable in tissue engineering.
However, the rapid degradation and the lack of mechanical and enzymatic stabilities of …