The early endosome (EE), also known as the sorting endosome (SE) is a crucial station for
the sorting of cargoes, such as receptors and lipids, through the endocytic pathways. The …

The purification of coated vesicles and the discovery of clathrin by Barbara Pearse in 1975
was a landmark in cell biology. Over the past 40 years, work from many labs has uncovered …

Live-cell imaging reveals the endolysosomal system as a complex and highly dynamic
network of interacting compartments. Distinct types of endosomes are discerned by kinetic …

Autophagy is a catabolic process essential for cell homeostasis, at the core of which is the
formation of double-membrane organelles called autophagosomes. Atg9 is the only known …

Autophagic protein degradation is mediated by autophagosomes that fuse with lysosomes,
where their contents are degraded. The membrane origins of autophagosomes may involve …

The two mannose 6-phosphate (M6P) receptors were identified because of their ability to
bind M6P-containing soluble acid hydrolases in the Golgi and transport them to the …

The cellular processes that govern neuronal function are highly complex, with many basic
cell biological pathways uniquely adapted to perform the elaborate information processing …

Long-term potentiation (LTP) of synaptic strength, the most established cellular model of
information storage in the brain, is expressed by an increase in the number of postsynaptic …

Foreign particles and apoptotic bodies are eliminated from the body by phagocytic
leucocytes. The initial stage of the elimination process is the internalization of the particles …

Organelles in the endocytic pathway are composed of a mosaic of structural and functional
regions. These regions consist, at least in part, of specialized protein–lipid domains within …