NF-κB in monocytes and macrophages–an inflammatory master regulator in multitalented immune cells

M Mussbacher, M Derler, J Basílio… - Frontiers in …, 2023 - frontiersin.org
Nuclear factor κB (NF-κB) is a dimeric transcription factor constituted by two of five protein
family members. It plays an essential role in inflammation and immunity by regulating the …

Cell type-specific roles of NF-κB linking inflammation and thrombosis

M Mussbacher, M Salzmann, C Brostjan… - Frontiers in …, 2019 - frontiersin.org
The transcription factor NF-κB is a central mediator of inflammation with multiple links to
thrombotic processes. In this review, we focus on the role of NF-κB signaling in cell types …

Mechanisms of NF-κB p65 and strategies for therapeutic manipulation

S Giridharan, M Srinivasan - Journal of inflammation research, 2018 - Taylor & Francis
The transcription factor NF-κB is a critical regulator of immune and inflammatory responses.
In mammals, the NF-κB/Rel family comprises five members: p50, p52, p65 (Rel-A), c-Rel …

Molecular basis of NF-κB signaling

J Napetschnig, H Wu - Annual review of biophysics, 2013 - annualreviews.org
NF-κB (nuclear factor kappa B) family transcription factors are master regulators of immune
and inflammatory processes in response to both injury and infection. In the latent state, NF …

The complexity of NF-κB signaling in inflammation and cancer

B Hoesel, JA Schmid - Molecular cancer, 2013 - Springer
The NF-κB family of transcription factors has an essential role in inflammation and innate
immunity. Furthermore, NF-κB is increasingly recognized as a crucial player in many steps of …

NF-κB regulation in the immune system

Q Li, IM Verma - Nature reviews immunology, 2002 - nature.com
The nuclear factor-κB (NF-κB)/REL family of transcription factors has a central role in
coordinating the expression of a wide variety of genes that control immune responses. There …

Signaling to NF-κB

MS Hayden, S Ghosh - Genes & development, 2004 - genesdev.cshlp.org
The transcription factor NF-κB has been the focus of intense investigation for nearly two
decades. Over this period, considerable progress has been made in determining the …

Regulation and function of NF-κB transcription factors in the immune system

S Vallabhapurapu, M Karin - Annual review of immunology, 2009 - annualreviews.org
The mammalian Rel/NF-κB family of transcription factors, including RelA, c-Rel, RelB, NF-
κB1 (p50 and its precursor p105), and NF-κB2 (p52 and its precursor p100), plays a central …

[HTML][HTML] Missing pieces in the NF-κB puzzle

S Ghosh, M Karin - cell, 2002 - cell.com
The regulation of the transcription factor NF-κB activity occurs at several levels including
controlled cytoplasmic-nuclear shuttling and modulation of its transcriptional activity. A …

The NF-κB pathway and cancer stem cells

AL Rinkenbaugh, AS Baldwin - Cells, 2016 - mdpi.com
The NF-κB transcription factor pathway is a crucial regulator of inflammation and immune
responses. Additionally, aberrant NF-κB signaling has been identified in many types of …