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NF-κB in monocytes and macrophages–an inflammatory master regulator in multitalented immune cells
Nuclear factor κB (NF-κB) is a dimeric transcription factor constituted by two of five protein
family members. It plays an essential role in inflammation and immunity by regulating the …
family members. It plays an essential role in inflammation and immunity by regulating the …
Cell type-specific roles of NF-κB linking inflammation and thrombosis
The transcription factor NF-κB is a central mediator of inflammation with multiple links to
thrombotic processes. In this review, we focus on the role of NF-κB signaling in cell types …
thrombotic processes. In this review, we focus on the role of NF-κB signaling in cell types …
Mechanisms of NF-κB p65 and strategies for therapeutic manipulation
S Giridharan, M Srinivasan - Journal of inflammation research, 2018 - Taylor & Francis
The transcription factor NF-κB is a critical regulator of immune and inflammatory responses.
In mammals, the NF-κB/Rel family comprises five members: p50, p52, p65 (Rel-A), c-Rel …
In mammals, the NF-κB/Rel family comprises five members: p50, p52, p65 (Rel-A), c-Rel …
Molecular basis of NF-κB signaling
NF-κB (nuclear factor kappa B) family transcription factors are master regulators of immune
and inflammatory processes in response to both injury and infection. In the latent state, NF …
and inflammatory processes in response to both injury and infection. In the latent state, NF …
The complexity of NF-κB signaling in inflammation and cancer
The NF-κB family of transcription factors has an essential role in inflammation and innate
immunity. Furthermore, NF-κB is increasingly recognized as a crucial player in many steps of …
immunity. Furthermore, NF-κB is increasingly recognized as a crucial player in many steps of …
NF-κB regulation in the immune system
The nuclear factor-κB (NF-κB)/REL family of transcription factors has a central role in
coordinating the expression of a wide variety of genes that control immune responses. There …
coordinating the expression of a wide variety of genes that control immune responses. There …
Signaling to NF-κB
The transcription factor NF-κB has been the focus of intense investigation for nearly two
decades. Over this period, considerable progress has been made in determining the …
decades. Over this period, considerable progress has been made in determining the …
Regulation and function of NF-κB transcription factors in the immune system
The mammalian Rel/NF-κB family of transcription factors, including RelA, c-Rel, RelB, NF-
κB1 (p50 and its precursor p105), and NF-κB2 (p52 and its precursor p100), plays a central …
κB1 (p50 and its precursor p105), and NF-κB2 (p52 and its precursor p100), plays a central …
[HTML][HTML] Missing pieces in the NF-κB puzzle
The regulation of the transcription factor NF-κB activity occurs at several levels including
controlled cytoplasmic-nuclear shuttling and modulation of its transcriptional activity. A …
controlled cytoplasmic-nuclear shuttling and modulation of its transcriptional activity. A …
The NF-κB pathway and cancer stem cells
The NF-κB transcription factor pathway is a crucial regulator of inflammation and immune
responses. Additionally, aberrant NF-κB signaling has been identified in many types of …
responses. Additionally, aberrant NF-κB signaling has been identified in many types of …