Osteoarthritis: pathogenic signaling pathways and therapeutic targets

Q Yao, X Wu, C Tao, W Gong, M Chen, M Qu… - Signal transduction and …, 2023 - nature.com
Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …

Modern-day environmental factors in the pathogenesis of osteoarthritis

F Berenbaum, IJ Wallace, DE Lieberman… - Nature Reviews …, 2018 - nature.com
The prevalence of osteoarthritis (OA) is rising for reasons that are not fully understood. In this
Opinion article, we review the possibility that OA is an evolutionary mismatch disease, which …

L-shaped association of serum 25-hydroxyvitamin D concentrations with cardiovascular and all-cause mortality in individuals with osteoarthritis: results from the …

Q **ao, B Cai, A Yin, H Huo, K Lan, G Zhou, L Shen… - BMC medicine, 2022 - Springer
Background The relationship between vitamin D status and mortality in patients with
osteoarthritis (OA) is unknown. This study investigated the associations of serum 25 …

[HTML][HTML] The burden for knee osteoarthritis among Chinese elderly: estimates from a nationally representative study

Q Liu, S Wang, J Lin, Y Zhang - Osteoarthritis and cartilage, 2018 - Elsevier
Objective To estimate the burden of knee osteoarthritis (OA) among Chinese population.
Design Individuals with symptomatic knee OA based on self-reported physician-diagnosed …

The burden of osteoarthritis due to high Body Mass Index in Iran from 1990 to 2019

M Darbandi, FK Shadmani, M Miryan, M Ghalandari… - Scientific Reports, 2023 - nature.com
High BMI related burden of knee and hip osteoarthritis (OA) is on a significant rise
worldwide. OA not only causes joint pain and stiffness, but it also leads to disability. This …

Development of a model for predicting the 4-year risk of symptomatic knee osteoarthritis in China: a longitudinal cohort study

L Wang, H Lu, H Chen, S **, M Wang… - Arthritis research & …, 2021 - Springer
Objectives We aimed to develop a model for predicting the 4-year risk of knee osteoarthritis
(KOA) based on survey data obtained via a random, nationwide sample of Chinese …

Trends and patterns of knee osteoarthritis in China: a longitudinal study of 17.7 million adults from 2008 to 2017

H Chen, J Wu, Z Wang, Y Wu, T Wu, Y Wu… - International Journal of …, 2021 - mdpi.com
Background: Knee osteoarthritis (KOA) provides many challenges on the healthcare system.
However, few studies have reported the epidemiology, particularly in a large population. Our …

The Western Ontario and McMaster Universities Osteoarthritis, Lequesne Algofunctional index, Arthritis Impact Measurement Scale-short form, and Visual Analogue …

R Salehi, L Valizadeh, H Negahban… - Disability and …, 2023 - Taylor & Francis
Purpose The goal of this study was to see whether the Western Ontario and McMaster
Universities Osteoarthritis index (WOMAC), Lequesne Algofunctional index and the Arthritis …

Total knee arthroplasty in Italy: reflections from the last fifteen years and projections for the next thirty

E Romanini, F Decarolis, I Luzi, G Zanoli… - International …, 2019 - Springer
Purpose Annual rates of knee arthroplasty are increasing in all developed countries,
imposing a significant economic and organizational burden; it is crucial to forecast the future …

Effects of protein supplementation combined with resistance exercise training on walking speed recovery in older adults with knee osteoarthritis and sarcopenia

CD Liao, SW Huang, HC Chen, YY Huang, TH Liou… - Nutrients, 2023 - mdpi.com
Knee osteoarthritis (KOA) is closely associated with sarcopenia, sharing the common
characteristics of muscle weakness and low physical performance. Resistance exercise …