Exosomes in the hypoxic TME: from release, uptake and biofunctions to clinical applications

G He, X Peng, S Wei, S Yang, X Li, M Huang, S Tang… - Molecular Cancer, 2022 - Springer
Hypoxia is a remarkable trait of the tumor microenvironment (TME). When facing selective
pressure, tumor cells show various adaptive characteristics, such as changes in the …

Mechanisms associated with biogenesis of exosomes in cancer

KM McAndrews, R Kalluri - Molecular cancer, 2019 - Springer
Intercellular communication between cellular compartments within the tumor and at distant
sites is critical for the development and progression of cancer. Exosomes have emerged as …

Extracellular vesicles and particles impact the systemic landscape of cancer

S Lucotti, CM Kenific, H Zhang, D Lyden - The EMBO journal, 2022 - embopress.org
Intercellular cross talk between cancer cells and stromal and immune cells is essential for
tumor progression and metastasis. Extracellular vesicles and particles (EVPs) are a …

Current knowledge and future perspectives on mesenchymal stem cell-derived exosomes as a new therapeutic agent

HS Joo, JH Suh, HJ Lee, ES Bang, JM Lee - International journal of …, 2020 - mdpi.com
Mesenchymal stem cells (MSCs) are on the cusp of regenerative medicine due to their
differentiation capacity, favorable culture conditions, ability to be manipulated in vitro, and …

[HTML][HTML] Scalable production of extracellular vesicles and its therapeutic values: a review

CY Ng, LT Kee, ME Al-Masawa, QH Lee… - International Journal of …, 2022 - mdpi.com
Extracellular vesicles (EVs) are minute vesicles with lipid bilayer membranes. EVs are
secreted by cells for intercellular communication. Recently, EVs have received much …

Biogenesis, membrane trafficking, functions, and next generation nanotherapeutics medicine of extracellular vesicles

S Gurunathan, MH Kang, M Qasim… - International Journal of …, 2021 - Taylor & Francis
Extracellular vesicles (EVs) are a heterogeneous group of membrane-limited vesicles and
multi-signal messengers loaded with biomolecules. Exosomes and ectosomes are two …

Emerging function and clinical values of exosomal microRNAs in cancer

M Wang, F Yu, H Ding, Y Wang, P Li, K Wang - Molecular therapy Nucleic …, 2019 - cell.com
Exosomes are a subset of membrane-bound extracellular vesicles with diameters ranging
from 30 to 100 nm. Exosomes enclose a variety of molecules, such as lipids, proteins, and …

Cardiac cell senescence: molecular mechanisms, key proteins and therapeutic targets

Y Luan, X Zhu, Y Jiao, H Liu, Z Huang, J Pei, Y Xu… - Cell Death …, 2024 - nature.com
Cardiac aging, particularly cardiac cell senescence, is a natural process that occurs as we
age. Heart function gradually declines in old age, leading to continuous heart failure, even in …

Trends in research on exosomes in cancer progression and anticancer therapy

D Sinha, S Roy, P Saha, N Chatterjee, A Bishayee - Cancers, 2021 - mdpi.com
Simple Summary Intensive research in the field of cancer biology has discovered a unique
mode of interplay between cells via extracellular bioactive vesicles called exosomes …

The roles of tumor-derived exosomes in non-small cell lung cancer and their clinical implications

H Zheng, Y Zhan, S Liu, J Lu, J Luo, J Feng… - Journal of Experimental & …, 2018 - Springer
Non-small cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer cases,
and it is one of the leading causes of cancer death in both men and women worldwide due …