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Nuclear cGAS: guard or prisoner?
Abstract cGAS, an innate immune sensor of cellular stress, recognizes double‐stranded
DNA mislocalized in the cytosol upon infection, mitochondrial stress, DNA damage, or …
DNA mislocalized in the cytosol upon infection, mitochondrial stress, DNA damage, or …
Virus-encoded histone doublets are essential and form nucleosome-like structures
The organization of genomic DNA into defined nucleosomes has long been viewed as a
hallmark of eukaryotes. This paradigm has been challenged by the identification of" …
hallmark of eukaryotes. This paradigm has been challenged by the identification of" …
[HTML][HTML] Chromatin-mediated epigenetic regulation of HSV-1 transcription as a potential target in antiviral therapy
The ability to establish, and reactivate from, latent infections is central to the biology and
pathogenesis of HSV-1. It also poses a strong challenge to antiviral therapy, as latent HSV-1 …
pathogenesis of HSV-1. It also poses a strong challenge to antiviral therapy, as latent HSV-1 …
Feline herpesvirus 1 (FHV-1) enters the cell by receptor-mediated endocytosis
ABSTRACT Feline herpesvirus type 1 (FHV-1) is an enveloped dsDNA virus belonging to
the Herpesviridae family and is considered one of the two primary viral etiological factors of …
the Herpesviridae family and is considered one of the two primary viral etiological factors of …
Histone H2A variant H2A. B is enriched in transcriptionally active and replicating HSV-1 lytic chromatin
E Flores Cortes, SM Saddoris, AK Owens… - Journal of …, 2024 - journals.asm.org
ABSTRACT Herpes simplex virus 1 (HSV-1) transcription is restricted in latently infected
neurons and the genomes are in mostly silenced chromatin, whereas all viral genes are …
neurons and the genomes are in mostly silenced chromatin, whereas all viral genes are …
Genome-wide analysis of G-quadruplexes in herpesvirus genomes
Background G-quadruplexes are increasingly recognized as regulatory elements in human,
animal, bacterial and plant genomes. The presence and function of G-quadruplexes are not …
animal, bacterial and plant genomes. The presence and function of G-quadruplexes are not …
BZLF1 interacts with chromatin remodelers promoting escape from latent infections with EBV
M Schaeffner, P Mrozek-Gorska… - Life science …, 2019 - life-science-alliance.org
A hallmark of EBV infections is its latent phase, when all viral lytic genes are repressed.
Repression results from a high nucleosome occupancy and epigenetic silencing by cellular …
Repression results from a high nucleosome occupancy and epigenetic silencing by cellular …
Chromatin dynamics and the transcriptional competence of HSV-1 genomes during lytic infections
During latent infections with herpes simplex virus 1 (HSV-1), viral transcription is restricted
and the genomes are mostly maintained in silenced chromatin, whereas in lytically infected …
and the genomes are mostly maintained in silenced chromatin, whereas in lytically infected …
Prasinovirus attack of Ostreococcus is furtive by day but savage by night
E Derelle, S Yau, H Moreau, NH Grimsley - Journal of Virology, 2018 - journals.asm.org
Prasinoviruses are large DNA viruses that infect diverse genera of green microalgae
worldwide in aquatic ecosystems, but molecular knowledge of their life cycles is lacking …
worldwide in aquatic ecosystems, but molecular knowledge of their life cycles is lacking …
The epigenetic landscapes of histone modifications on HSV-1 genome in human THP-1 cells
C Gao, L Chen, SB Tang, QY Long, JL He, NA Zhang… - Antiviral Research, 2020 - Elsevier
Histone positioning and modifications on viral genomes are important factors regulating
virus replication. To investigate the dynamics of modified histones on the viral genome and …
virus replication. To investigate the dynamics of modified histones on the viral genome and …