Nuclear cGAS: guard or prisoner?

CC de Oliveira Mann, KP Hopfner - The EMBO Journal, 2021 - embopress.org
Abstract cGAS, an innate immune sensor of cellular stress, recognizes double‐stranded
DNA mislocalized in the cytosol upon infection, mitochondrial stress, DNA damage, or …

Virus-encoded histone doublets are essential and form nucleosome-like structures

Y Liu, H Bisio, CM Toner, S Jeudy, N Philippe, K Zhou… - Cell, 2021 - cell.com
The organization of genomic DNA into defined nucleosomes has long been viewed as a
hallmark of eukaryotes. This paradigm has been challenged by the identification of" …

[HTML][HTML] Chromatin-mediated epigenetic regulation of HSV-1 transcription as a potential target in antiviral therapy

LM Schang, MY Hu, EF Cortes, K Sun - Antiviral research, 2021 - Elsevier
The ability to establish, and reactivate from, latent infections is central to the biology and
pathogenesis of HSV-1. It also poses a strong challenge to antiviral therapy, as latent HSV-1 …

Feline herpesvirus 1 (FHV-1) enters the cell by receptor-mediated endocytosis

A Synowiec, A Dąbrowska, M Pachota… - Journal of …, 2023 - journals.asm.org
ABSTRACT Feline herpesvirus type 1 (FHV-1) is an enveloped dsDNA virus belonging to
the Herpesviridae family and is considered one of the two primary viral etiological factors of …

Histone H2A variant H2A. B is enriched in transcriptionally active and replicating HSV-1 lytic chromatin

E Flores Cortes, SM Saddoris, AK Owens… - Journal of …, 2024 - journals.asm.org
ABSTRACT Herpes simplex virus 1 (HSV-1) transcription is restricted in latently infected
neurons and the genomes are in mostly silenced chromatin, whereas all viral genes are …

Genome-wide analysis of G-quadruplexes in herpesvirus genomes

B Biswas, M Kandpal, UK Jauhari, P Vivekanandan - BMC genomics, 2016 - Springer
Background G-quadruplexes are increasingly recognized as regulatory elements in human,
animal, bacterial and plant genomes. The presence and function of G-quadruplexes are not …

BZLF1 interacts with chromatin remodelers promoting escape from latent infections with EBV

M Schaeffner, P Mrozek-Gorska… - Life science …, 2019 - life-science-alliance.org
A hallmark of EBV infections is its latent phase, when all viral lytic genes are repressed.
Repression results from a high nucleosome occupancy and epigenetic silencing by cellular …

Chromatin dynamics and the transcriptional competence of HSV-1 genomes during lytic infections

MY Hu, DP Depledge, E Flores Cortes, J Breuer… - PLoS …, 2019 - journals.plos.org
During latent infections with herpes simplex virus 1 (HSV-1), viral transcription is restricted
and the genomes are mostly maintained in silenced chromatin, whereas in lytically infected …

Prasinovirus attack of Ostreococcus is furtive by day but savage by night

E Derelle, S Yau, H Moreau, NH Grimsley - Journal of Virology, 2018 - journals.asm.org
Prasinoviruses are large DNA viruses that infect diverse genera of green microalgae
worldwide in aquatic ecosystems, but molecular knowledge of their life cycles is lacking …

The epigenetic landscapes of histone modifications on HSV-1 genome in human THP-1 cells

C Gao, L Chen, SB Tang, QY Long, JL He, NA Zhang… - Antiviral Research, 2020 - Elsevier
Histone positioning and modifications on viral genomes are important factors regulating
virus replication. To investigate the dynamics of modified histones on the viral genome and …