A Hybrid drug which comprises the incorporation of two drug pharmacophores in one single
molecule are basically designed to interact with multiple targets or to amplify its effect …

Cancer is one of the leading causes of death globally, around 10 million deaths are reported
every year due to cancer. Some clinically approved anticancer drugs play a riveting role in …

Herein we report the synthesis of two series of novel 4/3-((4-oxo-5-(2-oxoindolin-3-ylidene)
thiazolidin-2-ylidene) amino) benzenesulfonamides (4a-m and 7a-g). All the newly prepared …

Cancer is one of the life-threatening diseases accountable for millions of demises globally.
The inadequate effectiveness of the existing chemotherapy and its harmful effects has …

In an attempt to develop potent anti-tubulin agents against most dreadful disease cancer, a
library of 28 novel triazole tethered isatin-coumarin hybrids were synthesized by click …

Isatin and azole moieties, which have the ability to form various noncovalent interactions
with different therapeutic targets, are common pharmacophores in drug development. Isatin …

A hybrid pharmacophore approach was adopted to design and synthesize new series of
isatin–pyridine hybrids. All the newly prepared hybrids (5a–o, 8 and 11a–d) were in vitro …

The synthesis and antitumor activity screening of novel isatin based conjugates with
thiazolidine and pyrazoline moieties were performed. Reaction of 3, 5‐diaryl‐4, 5 …

Abstract Treatment of patients with triple-negative breast cancer (TNBC) is challenging due
to the absence of well-defined molecular targets and the heterogeneity of such disease. In …

In connection with our research program on the development of new isatin-based anticancer
candidates, herein we report the synthesis of two novel series of thiazolidinone-isatin …