[HTML][HTML] DNA repair targeted therapy: The past or future of cancer treatment?
NS Gavande, PS VanderVere-Carozza… - Pharmacology & …, 2016 - Elsevier
The repair of DNA damage is a complex process that relies on particular pathways to
remedy specific types of damage to DNA. The range of insults to DNA includes small …
remedy specific types of damage to DNA. The range of insults to DNA includes small …
Human apurinic/apyrimidinic endonuclease 1
M Li, DM Wilson III - Antioxidants & redox signaling, 2014 - liebertpub.com
Significance: Human apurinic/apyrimidinic endonuclease 1 (APE1, also known as REF-1)
was isolated based on its ability to cleave at AP sites in DNA or activate the DNA binding …
was isolated based on its ability to cleave at AP sites in DNA or activate the DNA binding …
Probing and regulating the activity of cellular enzymes by using DNA tetrahedron nanostructures
Given the essential role of apurinic/apyrimidinic endonuclease (APE1) in gene repair and
cancer progression, we report a novel approach for probing and regulating cellular APE1 …
cancer progression, we report a novel approach for probing and regulating cellular APE1 …
Revisiting two decades of Research focused on Targeting APE1 for Cancer Therapy: the pros and cons
APE1 is an essential endodeoxyribonuclease of the base excision repair pathway that
maintains genome stability. It was identified as a pivotal factor favoring tumor progression …
maintains genome stability. It was identified as a pivotal factor favoring tumor progression …
Copper nanocluster composites for analytical (bio)-sensing and imaging: a review
J Mu, Y Peng, Z Shi, D Zhang, Q Jia - Microchimica Acta, 2021 - Springer
As an ideal substitute for traditional organic fluorescent dyes or up-conversion
nanomaterials, copper nanoclusters (CuNCs) have developed rapidly and have been …
nanomaterials, copper nanoclusters (CuNCs) have developed rapidly and have been …
Inhibitors of nuclease and redox activity of apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1)
SS Laev, NF Salakhutdinov, OI Lavrik - Bioorganic & medicinal chemistry, 2017 - Elsevier
Human apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1) is a
multifunctional protein which is essential in the base excision repair (BER) pathway of DNA …
multifunctional protein which is essential in the base excision repair (BER) pathway of DNA …
PubChem applications in drug discovery: a bibliometric analysis
Highlights•We investigated PubChem applications by a bibliometric analysis of research
articles.•PubChem resource was accessed globally for various research areas.•PubChem …
articles.•PubChem resource was accessed globally for various research areas.•PubChem …
ATR kinase activation in G1 phase facilitates the repair of ionizing radiation-induced DNA damage
The kinase ATR is activated by RPA-coated single-stranded DNA generated at aberrant
replicative structures and resected double strand breaks. While many hundred candidate …
replicative structures and resected double strand breaks. While many hundred candidate …
[HTML][HTML] Nanoparticle mediated silencing of DNA repair sensitizes pediatric brain tumor cells to γ-irradiation
Medulloblastoma (MB) and ependymoma (EP) are the most common pediatric brain tumors,
afflicting 3000 children annually. Radiotherapy (RT) is an integral component in the …
afflicting 3000 children annually. Radiotherapy (RT) is an integral component in the …
Repair of 3-methyladenine and abasic sites by base excision repair mediates glioblastoma resistance to temozolomide
MS Bobola, DD Kolstoe, A Blank… - Frontiers in …, 2012 - frontiersin.org
Alkylating agents have long played a central role in the adjuvant therapy of glioblastoma
(GBM). More recently, inclusion of temozolomide (TMZ), an orally administered methylating …
(GBM). More recently, inclusion of temozolomide (TMZ), an orally administered methylating …