[HTML][HTML] What is the key mediator of the neurovascular coupling response?
PS Hosford, AV Gourine - Neuroscience & Biobehavioral Reviews, 2019 - Elsevier
The mechanisms of neurovascular coupling contribute to ensuring brain energy supply is
sufficient to meet demand. Despite significant research interest, the mechanisms underlying …
sufficient to meet demand. Despite significant research interest, the mechanisms underlying …
Dysregulation of Ion Channels and transporters and blood-brain barrier dysfunction in Alzheimer's Disease and Vascular Dementia
R Liu, JM Collier, NH Abdul-Rahman… - Aging and …, 2024 - pmc.ncbi.nlm.nih.gov
The blood-brain barrier (BBB) plays a critical role in maintaining ion and fluid homeostasis,
essential for brain metabolism and neuronal function. Regulation of nutrient, water, and ion …
essential for brain metabolism and neuronal function. Regulation of nutrient, water, and ion …
Astrocytes monitor cerebral perfusion and control systemic circulation to maintain brain blood flow
N Marina, IN Christie, A Korsak, M Doronin… - Nature …, 2020 - nature.com
Astrocytes provide neurons with essential metabolic and structural support, modulate
neuronal circuit activity and may also function as versatile surveyors of brain milieu, tuned to …
neuronal circuit activity and may also function as versatile surveyors of brain milieu, tuned to …
Precapillary sphincters and pericytes at first-order capillaries as key regulators for brain capillary perfusion
Rises in local neural activity trigger local increases of cerebral blood flow, which is essential
to match local energy demands. However, the specific location of microvascular flow control …
to match local energy demands. However, the specific location of microvascular flow control …
Opening of ATP sensitive potassium channels causes migraine attacks with aura
MAM Al-Karagholi, H Ghanizada, CAW Nielsen… - Brain, 2021 - academic.oup.com
Migraine afflicts more than one billion individuals worldwide and is a leading cause of years
lived with disability. In about a third of individuals with migraine aura occur in relation to …
lived with disability. In about a third of individuals with migraine aura occur in relation to …
[HTML][HTML] Partial MCT1 invalidation protects against diet-induced non-alcoholic fatty liver disease and the associated brain dysfunction
A Hadjihambi, C Konstantinou, J Klohs, K Monsorno… - Journal of …, 2023 - Elsevier
Background & Aims Non-alcoholic fatty liver disease (NAFLD) has been associated with
mild cerebral dysfunction and cognitive decline, although the exact pathophysiological …
mild cerebral dysfunction and cognitive decline, although the exact pathophysiological …
Brain capillary pericytes are metabolic sentinels that control blood flow through a KATP channel-dependent energy switch
A Hariharan, CD Robertson, DCG Garcia, TA Longden - Cell reports, 2022 - cell.com
Despite the abundance of capillary thin-strand pericytes and their proximity to neurons and
glia, little is known of the contributions of these cells to the control of brain hemodynamics …
glia, little is known of the contributions of these cells to the control of brain hemodynamics …
Pericytes as the Orchestrators of Vasculature and Adipogenesis
CC Picoli, A Birbrair, Z Li - Genes, 2024 - mdpi.com
Pericytes (PCs) are located surrounding the walls of small blood vessels, particularly
capillaries and microvessels. In addition to their functions in maintaining vascular integrity …
capillaries and microvessels. In addition to their functions in maintaining vascular integrity …
[HTML][HTML] KCNJ8/ABCC9-containing K-ATP channel modulates brain vascular smooth muscle development and neurovascular coupling
K Ando, L Tong, D Peng, E Vázquez-Liébanas… - Developmental Cell, 2022 - cell.com
Loss-or gain-of-function mutations in ATP-sensitive potassium channel (K-ATP)-encoding
genes, KCNJ8 and ABCC9, cause human central nervous system disorders with unknown …
genes, KCNJ8 and ABCC9, cause human central nervous system disorders with unknown …
Aging exacerbates impairments of cerebral blood flow autoregulation and cognition in diabetic rats
S Wang, W Lv, H Zhang, Y Liu, L Li, JR Jefferson… - Geroscience, 2020 - Springer
Diabetes mellitus (DM) is a leading risk factor for aging-related dementia; however, the
underlying mechanisms are not well understood. The present study, utilizing a non-obese …
underlying mechanisms are not well understood. The present study, utilizing a non-obese …