Metabolic engineering: methodologies and applications

MJ Volk, VG Tran, SI Tan, S Mishra, Z Fatma… - Chemical …, 2022 - ACS Publications
Metabolic engineering aims to improve the production of economically valuable molecules
through the genetic manipulation of microbial metabolism. While the discipline is a little over …

A comprehensive metabolic map for production of bio-based chemicals

SY Lee, HU Kim, TU Chae, JS Cho, JW Kim, JH Shin… - Nature …, 2019 - nature.com
Production of industrial chemicals using renewable biomass feedstock is becoming
increasingly important to address limited fossil resources, climate change and other …

Combining mechanistic and machine learning models for predictive engineering and optimization of tryptophan metabolism

J Zhang, SD Petersen, T Radivojevic, A Ramirez… - Nature …, 2020 - nature.com
Through advanced mechanistic modeling and the generation of large high-quality datasets,
machine learning is becoming an integral part of understanding and engineering living …

50th Anniversary Perspective: There Is a Great Future in Sustainable Polymers

DK Schneiderman, MA Hillmyer - Macromolecules, 2017 - ACS Publications
It is likely that a half-century ago even enthusiastic and optimistic proponents of the synthetic
polymer industry (Mr. McGuire included) could not have predicted the massive scale on …

[HTML][HTML] Pseudomonas putida as a functional chassis for industrial biocatalysis: from native biochemistry to trans-metabolism

PI Nikel, V de Lorenzo - Metabolic engineering, 2018 - Elsevier
The itinerary followed by Pseudomonas putida from being a soil-dweller and plant colonizer
bacterium to become a flexible and engineer-able platform for metabolic engineering stems …

Semi-biological approaches to solar-to-chemical conversion

X Fang, S Kalathil, E Reisner - Chemical Society Reviews, 2020 - pubs.rsc.org
This review presents a comprehensive summary of the recent development in semi-artificial
photosynthesis, a biological-material hybrid approach to solar-to-chemical conversion that …

[HTML][HTML] Waste to bioplastics: How close are we to sustainable polyhydroxyalkanoates production?

K Khatami, M Perez-Zabaleta, I Owusu-Agyeman… - Waste Management, 2021 - Elsevier
Increased awareness of environmental sustainability with associated strict environmental
regulations has incentivized the pursuit of novel materials to replace conventional petroleum …

Whole-cell biocatalysts by design

B Lin, Y Tao - Microbial cell factories, 2017 - Springer
Whole-cell biocatalysts provide unique advantages and have been widely used for the
efficient biosynthesis of value-added fine and bulk chemicals, as well as pharmaceutically …

A brief history of synthetic biology

DE Cameron, CJ Bashor, JJ Collins - Nature Reviews Microbiology, 2014 - nature.com
The ability to rationally engineer microorganisms has been a long-envisioned goal dating
back more than a half-century. With the genomics revolution and rise of systems biology in …

Bioremediation 3.0: engineering pollutant-removing bacteria in the times of systemic biology

P Dvořák, PI Nikel, J Damborský, V de Lorenzo - Biotechnology advances, 2017 - Elsevier
Elimination or mitigation of the toxic effects of chemical waste released to the environment
by industrial and urban activities relies largely on the catalytic activities of microorganisms …