Molecular biomarkers in acute myeloid leukemia
Acute myeloid leukemia (AML) is the most common acute leukemia in adults. The
pathophysiology of this disease is just beginning to be understood at the cellular and …
pathophysiology of this disease is just beginning to be understood at the cellular and …
Pharmacological inhibition of LSD1 for cancer treatment
GJ Yang, PM Lei, SY Wong, DL Ma, CH Leung - Molecules, 2018 - mdpi.com
Lysine-specific demethylase 1A (LSD1, also named KDM1A) is a demethylase that can
remove methyl groups from histones H3K4me1/2 and H3K9me1/2. It is aberrantly expressed …
remove methyl groups from histones H3K4me1/2 and H3K9me1/2. It is aberrantly expressed …
[HTML][HTML] TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes
Background The molecular determinants of clinical responses to decitabine therapy in
patients with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS) are …
patients with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS) are …
A comprehensive review of lysine-specific demethylase 1 and its roles in cancer
A Hosseini, S Minucci - Epigenomics, 2017 - Taylor & Francis
Histone methylation plays a key role in the regulation of chromatin structure, and its
dynamics regulates important cellular processes. The investigation of the role of alterations …
dynamics regulates important cellular processes. The investigation of the role of alterations …
Therapeutic potential of targeting LSD1/KDM1A in cancers
X Zhang, X Wang, T Wu, W Yin, J Yan, Y Sun… - Pharmacological …, 2022 - Elsevier
LSD1 was the first histone demethylase identified by Professor Shi Yang and his team
members in 2004. LSD1 employs FAD as its cofactor, which catalyzes the demethylation of …
members in 2004. LSD1 employs FAD as its cofactor, which catalyzes the demethylation of …
IGF2 is up-regulated by epigenetic mechanisms in hepatocellular carcinomas and is an actionable oncogene product in experimental models
I Martinez-Quetglas, R Pinyol, D Dauch, S Torrecilla… - Gastroenterology, 2016 - Elsevier
Background & Aims Effective treatments are urgently needed for hepatocellular carcinoma
(HCC), which is usually diagnosed at advanced stages. Signaling via the insulin-like growth …
(HCC), which is usually diagnosed at advanced stages. Signaling via the insulin-like growth …
Roles and epigenetic regulation of epithelial–mesenchymal transition and its transcription factors in cancer initiation and progression
JY Lee, G Kong - Cellular and molecular life sciences, 2016 - Springer
The epithelial–mesenchymal transition (EMT) is a crucial developmental process by which
epithelial cells undergo a mesenchymal phenotypic change. During EMT, epigenetic …
epithelial cells undergo a mesenchymal phenotypic change. During EMT, epigenetic …
The genetic and molecular pathogenesis of myelodysplastic syndromes
RM Shallis, R Ahmad, AM Zeidan - European journal of …, 2018 - Wiley Online Library
Myelodysplastic syndromes (MDS) comprise a diverse group of clonal and malignant
myeloid disorders characterized by ineffective hematopoiesis, resultant peripheral …
myeloid disorders characterized by ineffective hematopoiesis, resultant peripheral …
N6-Adenosine Methylation (m6A) RNA Modification: an Emerging Role in Cardiovascular Diseases
Y Chen, X Ouyang, X Yu, P Novák, L Zhou… - Journal of …, 2021 - Springer
Abstract N6-methyladenosine (m 6 A) is the most abundant and prevalent epigenetic
modification of mRNA in mammals. This dynamic modification is regulated by m 6 A …
modification of mRNA in mammals. This dynamic modification is regulated by m 6 A …
Epigenetics in cancer: a hematological perspective
For several decades, we have known that epigenetic regulation is disrupted in cancer.
Recently, an increasing body of data suggests epigenetics might be an intersection of …
Recently, an increasing body of data suggests epigenetics might be an intersection of …