Ligand design strategies to increase stability of gadolinium-based magnetic resonance imaging contrast agents

TJ Clough, L Jiang, KL Wong, NJ Long - Nature communications, 2019‏ - nature.com
Gadolinium (III) complexes have been widely utilised as magnetic resonance imaging (MRI)
contrast agents for decades. In recent years however, concerns have developed about their …

Advancement of metal compounds as therapeutic and diagnostic metallodrugs: Current frontiers and future perspectives

I Yousuf, M Bashir, F Arjmand, S Tabassum - Coordination Chemistry …, 2021‏ - Elsevier
Coordination compounds on account of distinctive features of metal ions that include
variable oxidation states, diverse range of geometries and coordination numbers …

Being excited by lanthanide coordination complexes: aqua species, chirality, excited-state chemistry, and exchange dynamics

D Parker, RS Dickins, H Puschmann… - Chemical …, 2002‏ - ACS Publications
Over the past 10 years there has been a resurgence of interest in the coordination chemistry
of lanthanide complexes in aqueous solution. Excitement in this work may be related to an …

Biomedical applications of macrocyclic ligand complexes

RE Mewis, SJ Archibald - Coordination Chemistry Reviews, 2010‏ - Elsevier
Macrocyclic chelators can form highly stable complexes with transition metals and
lanthanides. In this review, the recent advances towards biomedical applications of …

Gadolinium (III) complexes as MRI contrast agents: ligand design and properties of the complexes

P Hermann, J Kotek, V Kubíček, I Lukeš - Dalton Transactions, 2008‏ - pubs.rsc.org
Magnetic resonance imaging is a commonly used diagnostic method in medicinal practice
as well as in biological and preclinical research. Contrast agents (CAs), which are often …

[HTML][HTML] Poly (amidoamine), polypropylenimine, and related dendrimers and dendrons possessing different 1→ 2 branching motifs: An overview of the divergent …

GR Newkome, CD Shreiner - Polymer, 2008‏ - Elsevier
This review presents an overview of 1→ 2 branched dendrimers and dendrons, created by a
divergent procedure, from their synthesis to modern day applications. The first members of …

Dual purpose Prussian blue nanoparticles for cellular imaging and drug delivery: a new generation of T 1-weighted MRI contrast and small molecule delivery agents

M Shokouhimehr, ES Soehnlen, J Hao… - Journal of Materials …, 2010‏ - pubs.rsc.org
A simple and improved aqueous synthetic procedure using flash heating for preparing
biocompatible Prussian blue nanoparticles (PBNPs) with the single-crystal-like feature was …

How to determine free Gd and free ligand in solution of Gd chelates. A technical note

A Barge, G Cravotto, E Gianolio… - Contrast media & …, 2006‏ - Wiley Online Library
Gd (III) chelates are often used as reporting probes in magnetic resonance imaging
applications. Their use relies on the assumption that their high stability ensures against the …

Complexes of tetraazacycles bearing methylphosphinic/phosphonic acid pendant arms with copper (II), zinc (II) and lanthanides (III). A comparison with their acetic …

I Lukeš, J Kotek, P Vojtı́šek, P Hermann - Coordination Chemistry Reviews, 2001‏ - Elsevier
A comparison of complexing properties of cyclen and cyclam derivatives containing acetic
acid pendant arms on one hand and their methylphosphonic or methylphosphinic acid …

Complexing Mechanism of the Lanthanide Cations Eu3+, Gd3+, and Tb3+ with 1,4,7,10‐Tetrakis(carboxymethyl)‐1,4,7,10‐tetraazacyclododecane (dota) …

J Moreau, E Guillon, JC Pierrard… - … A European Journal, 2004‏ - Wiley Online Library
Complexation of the lanthanides Eu3+, Gd3+, and Tb3+ with 1, 4, 7, 10‐tetrakis
(carboxymethyl)‐1, 4, 7, 10‐tetraazacyclododecane (dota) has been studied in solution by …