Physical activity promotes brain development through serotonin during early childhood

JQ **g, SJ Jia, CJ Yang - Neuroscience, 2024 - Elsevier
Early childhood serves as a critical period for neural development and skill acquisition when
children are extremely susceptible to the external environment and experience. As a crucial …

Therapeutic mechanisms of psychedelics and entactogens

BD Heifets, DE Olson - Neuropsychopharmacology, 2024 - nature.com
Recent clinical and preclinical evidence suggests that psychedelics and entactogens may
produce both rapid and sustained therapeutic effects across several indications. Currently …

Modulation of 5-HT release by dynorphin mediates social deficits during opioid withdrawal

MB Pomrenze, DFC Pinto, PA Neumann, P Llorach… - Neuron, 2022 - cell.com
Social isolation during opioid withdrawal is a major contributor to the current opioid
addiction crisis. We find that sociability deficits during protracted opioid withdrawal in mice …

Neural circuits regulating prosocial behaviors

JJ Walsh, DJ Christoffel, RC Malenka - Neuropsychopharmacology, 2023 - nature.com
Positive, prosocial interactions are essential for survival, development, and well-being.
These intricate and complex behaviors are mediated by an amalgamation of neural circuit …

Context-specific functions of chromatin remodellers in development and disease

S Gourisankar, A Krokhotin, W Wenderski… - Nature Reviews …, 2024 - nature.com
Chromatin remodellers were once thought to be highly redundant and nonspecific in their
actions. However, recent human genetic studies demonstrate remarkable biological …

Towards the convergent therapeutic potential of G protein‐coupled receptors in autism spectrum disorders

A Annamneedi, C Gora, A Dudas… - British journal of …, 2023 - Wiley Online Library
Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two
core symptoms: deficits in social interaction and communication, and stereotyped …

MDMA enhances empathy-like behaviors in mice via 5-HT release in the nucleus accumbens

B Rein, K Raymond, C Boustani, S Tuy, J Zhang… - Science …, 2024 - science.org
MDMA (3, 4-methylenedioxymethamphetamine) is a psychoactive drug with powerful
prosocial effects. While MDMA is sometimes termed an “empathogen,” empirical studies …

Metformin Alleviates Autistic‐Like Behaviors Elicited by High‐Fat Diet Consumption and Modulates the Crosstalk Between Serotonin and Gut Microbiota in Mice

W Deng, H Ke, S Wang, Z Li, S Li, P Lv… - Behavioural …, 2022 - Wiley Online Library
The biological mechanisms linking diet‐related obesity and autistic behaviors remain
unclear. Metformin has proven to be beneficial in the treatment of many syndromes …

FPT, a 2-Aminotetralin, Is a Potent Serotonin 5-HT1A, 5-HT1B, and 5-HT1D Receptor Agonist That Modulates Cortical Electroencephalogram Activity in Adult Fmr1 …

TS Saraf, RP McGlynn, OM Bhatavdekar… - ACS chemical …, 2022 - ACS Publications
There are no approved medicines for fragile X syndrome (FXS), a monogenic,
neurodevelopmental disorder. Electroencephalogram (EEG) studies show alterations in …

Attenuation of Autism-like Behaviors by an Anthocyanin-Rich Extract from Portuguese Blueberries via Microbiota–Gut–Brain Axis Modulation in a Valproic Acid Mouse …

D Serra, JF Henriques, FJ Sousa, M Laranjo… - International Journal of …, 2022 - mdpi.com
Autism Spectrum Disorders (ASDs) are a group of neurodevelopmental pathologies whose
current treatment is neither curative nor effective. Anthocyanins are naturally occurring …