Endogenous retroviruses (ERVs) are evolutionary remnants of retroviral infections in which
the viral genome became embedded as a dormant regulatory element within the host …

Chimeric antigen receptor (CAR) T cell therapy effectively treats human cancer, but the loss
of the antigen recognized by the CAR poses a major obstacle. We found that in vivo vaccine …

Simple Summary This mini-review summarizes the up-to-date progress in develo**
anticancer therapies based on cutting-edge strategies employing short peptides. This work …

Although significant advances in immunotherapy have revolutionized the treatment of many
cancer types over the past decade, the field of vaccine therapy, an important component of …

Breast cancer is one of the leading causes of death that affects the female population
worldwide. Despite advances in treatments and a greater understanding of the disease …

Mimotopes of short CD8+ T-cell epitopes generally comprise one or more mutated residues,
and can increase the immunogenicity and function of peptide cancer vaccines. We recently …

Cytokine therapies are potent immunotherapy agents but exhibit severe dose-limiting
toxicities. One strategy to overcome this involves engineering cytokines for intratumoral …

Cancer immunotherapy targets immune cells to trigger a highly specific, long-lasting anti-
tumor response. With the clinical success of immune checkpoint blockade and the …

Major histocompatibility complex (MHC) proteins play a critical role in the adaptive immune
system, presenting peptide fragments on the surface of cells for surveillance by T cells. In …

Detailed molecular understanding of the human organism is essential to develop effective
therapies. Saccharomyces cerevisiae has been used extensively for acquiring insights into …