Dynamic nuclear polarization for sensitivity enhancement in biomolecular solid-state NMR

T Biedenbänder, V Aladin, S Saeidpour… - Chemical …, 2022 - ACS Publications
Solid-state NMR with magic-angle spinning (MAS) is an important method in structural
biology. While NMR can provide invaluable information about local geometry on an atomic …

Ubiquitination and the regulation of membrane proteins

N Foot, T Henshall, S Kumar - Physiological reviews, 2017 - journals.physiology.org
Newly synthesized transmembrane proteins undergo a series of steps to ensure that only
the required amount of correctly folded protein is localized to the membrane. The regulation …

Sampling alternative conformational states of transporters and receptors with AlphaFold2

D Del Alamo, D Sala, HS Mchaourab, J Meiler - Elife, 2022 - elifesciences.org
Equilibrium fluctuations and triggered conformational changes often underlie the functional
cycles of membrane proteins. For example, transporters mediate the passage of molecules …

Artificial cells for in vivo biomedical applications through red blood cell biomimicry

J Waeterschoot, W Gosselé, Š Lemež… - Nature …, 2024 - nature.com
Recent research in artificial cell production holds promise for the development of delivery
agents with therapeutic effects akin to real cells. To succeed in these applications, these …

[HTML][HTML] Lipid membrane mimetics in functional and structural studies of integral membrane proteins

S Majeed, AB Ahmad, U Sehar, ER Georgieva - Membranes, 2021 - mdpi.com
Background: Open Access Editor's Choice Review Lipid Membrane Mimetics in Functional
and Structural Studies of Integral Membrane Proteins by Saman Majeed 1, Akram Bani …

Selection of DNA-encoded chemical libraries against endogenous membrane proteins on live cells

Y Huang, L Meng, Q Nie, Y Zhou, L Chen, S Yang… - Nature Chemistry, 2021 - nature.com
Membrane proteins on the cell surface perform a myriad of biological functions; however,
ligand discovery for membrane proteins is highly challenging, because a natural cellular …

Structure and mechanism of the cation–chloride cotransporter NKCC1

TA Chew, BJ Orlando, J Zhang, NR Latorraca, A Wang… - Nature, 2019 - nature.com
Cation–chloride cotransporters (CCCs) mediate the electroneutral transport of chloride,
potassium and/or sodium across the membrane. They have critical roles in regulating cell …

Lipid nanodiscs for high-resolution NMR studies of membrane proteins

U Günsel, F Hagn - Chemical Reviews, 2021 - ACS Publications
Membrane proteins (MPs) play essential roles in numerous cellular processes. Because
around 70% of the currently marketed drugs target MPs, a detailed understanding of their …

A perspective on the prospective use of AI in protein structure prediction

R Versini, S Sritharan, B Aykac Fas… - Journal of Chemical …, 2023 - ACS Publications
AlphaFold2 (AF2) and RoseTTaFold (RF) have revolutionized structural biology, serving as
highly reliable and effective methods for predicting protein structures. This article explores …

Feeling the heat: searching for plant thermosensors

L Dai Vu, K Gevaert, I De Smet - Trends in plant science, 2019 - cell.com
To draw the complete picture of plant thermal signaling, it is important to find the missing
links between the temperature cue, the actual sensing, and the subsequent response. In this …