Nitric oxide (NO), an endogenous, free radical, highly unstable, diatomic gaseous molecule,
plays crucial roles in several physiological and pathological processes. It has attracted …

Metal ions play important roles in biological processes, 1 and the field of knowledge
concerned with the application of inorganic chemistry to therapy or diagnosis of disease is …

Our desire to understand how the individual molecules that make up cells organize, interact,
and communicate to form living systems has led to the burgeoning field of chemical biology …

Many first-line treatments for neglected tropical diseases identified by the World Health
Organization (WHO) are limited by one or more of the following: the development of drug …

The widespread use of antibiotics has resulted in the emergence of drug-resistant
populations of microorganisms. Clearly, one can see the need to develop new, more …

Chagas disease is a neglected tropical disease caused by the protozoan Trypanosoma
cruzi. Currently, only nitroheterocyclic nifurtimox (NFX) and benznidazole (BNZ) are …

Nitric oxide plays an important role in various biological processes, such as
neurotransmission, blood pressure control, immunological responses, and antioxidant …

Low molecular weight and high molecular weight metal ion binders present in blood plasma
are shortly described. The binding of vanadium and ruthenium complexes by these …

Ruthenium is seldom mentioned in microbiology texts, due to the fact that this metal has no
known, essential roles in biological systems, nor is it generally considered toxic. Since the …

Trypanosoma cruzi infection triggers substantial production of nitric oxide (NO), which has
been shown to have protective and toxic effects on the host's immune system. Sensing of …