X-chromosome inactivation (XCI) is the epigenetic mechanism that ensures X-linked dosage
compensation between cells of females (XX karyotype) and males (XY). XCI is essential for …

X chromosome inactivation and genomic imprinting are classic epigenetic processes that
cause disease when not appropriately regulated in mammals. Whereas X chromosome …

Long noncoding RNAs (lncRNAs) have gained widespread attention in recent years as a
potentially new and crucial layer of biological regulation. lncRNAs of all kinds have been …

CTCF is a highly conserved zinc finger protein implicated in diverse regulatory functions,
including transcriptional activation/repression, insulation, imprinting, and X chromosome …

To accommodate genomes in the limited space of the cell nucleus and ensure the correct
execution of gene expression programs, genomes are packaged in complex fashion in the …

In somatic nuclei of female therian mammals, the two X chromosomes display very different
chromatin states: One X is typically euchromatic and transcriptionally active, and the other is …

Accumulating evidence converges on the possibility that chromosomes interact with each
other to regulate transcription in trans. To systematically explore the epigenetic dimension of …

Genomes are more than linear sequences. In vivo they exist as elaborate physical
structures, and their functional properties are strongly determined by their cellular …

Once protein-coding, the X-inactivation center (**c) is now dominated by large noncoding
RNAs (ncRNA). X chromosome inactivation (XCI) equalizes gene expression between …

Changes in human DNA methylation patterns are an important feature of cancer
development and progression and a potential role in other conditions such as …