Recent advances in azaborine chemistry

PG Campbell, AJV Marwitz… - Angewandte Chemie …, 2012 - Wiley Online Library
The chemistry of organoboron compounds has been primarily dominated by their use as
powerful reagents in synthetic organic chemistry. Recently, the incorporation of boron as …

Boron in drug discovery: carboranes as unique pharmacophores in biologically active compounds

F Issa, M Kassiou, LM Rendina - Chemical reviews, 2011 - ACS Publications
Boron, in the form of boric acid, has played a role in medicine as a mild antiseptic and an
eye wash since its preparation from borax in the 18th century. However, the use of boron in …

Synthesis and Suzuki–Miyaura cross-coupling of alkyl amine-boranes. A boryl radical-enabled Strategy

CS Buettner, C Stavagna, MJ Tilby… - Journal of the …, 2024 - ACS Publications
Alkyl organoborons are powerful materials for the construction of C (sp 3)–C (sp 2) bonds,
predominantly via Suzuki–Miyaura cross-coupling. These species are generally assembled …

The versatility of boron in biological target engagement

DB Diaz, AK Yudin - Nature Chemistry, 2017 - nature.com
Boron-containing molecules have been extensively used for the purposes of chemical
sensing, biological probe development and drug discovery. Due to boron's empty p orbital, it …

Modular synthesis of 1, 2-azaborines via ring-opening BN-isostere benzannulation

H Lyu, TH Tugwell, Z Chen, GA Kukier, A Turlik… - Nature Chemistry, 2024 - nature.com
Azaborines represent a unique class of benzene isosteres that have attracted interest for
develo** pharmaceuticals with better potency and bioavailability. However, it remains a …

Site-Selective and Stereoselective trans-Hydroboration of 1,3-Enynes Catalyzed by 1,4-Azaborine-Based Phosphine–Pd Complex

S Xu, Y Zhang, B Li, SY Liu - Journal of the American Chemical …, 2016 - ACS Publications
A concise synthesis of monobenzofused 1, 4-azaborine phosphine ligands (Senphos) is
described. These Senphos ligands uniquely support Pd-catalyzed trans-selective …

Construction of Boron-Containing Aromatic Heterocycles

B Su, R Kinjo - Synthesis, 2017 - thieme-connect.com
Boron-containing aromatic systems exhibit unique electronic properties and reactivities that
have been extensively studied for a long time. This review highlights the recent …

Recent developments in azaborinine chemistry

G Bélanger‐Chabot, H Braunschweig… - European Journal of …, 2017 - Wiley Online Library
Recent years have witnessed rapid advances in the field of BN/CC isosterism, particularly in
the case of azaborinines. Examples of each isomer have now been synthesized and …

Hydrogen Storage by Boron− Nitrogen Heterocycles: A Simple Route for Spent Fuel Regeneration

PG Campbell, LN Zakharov, DJ Grant… - Journal of the …, 2010 - ACS Publications
We describe a new hydrogen storage platform based on well-defined BN heterocyle
materials. Specifically, we demonstrate that regeneration of the spent fuel back to the …

Medicinal chemistry profiling of monocyclic 1, 2‐azaborines

P Zhao, DO Nettleton, RG Karki, FJ Zécri… - ChemMedChem, 2017 - Wiley Online Library
The first examples of biologically active monocyclic 1, 2‐azaborines have been synthesized
and demonstrated to exhibit not only improved in vitro aqueous solubility in comparison with …