Receptors enable cells to detect, process and respond to information about their
environments. Over the past two decades, synthetic biologists have repurposed physical …

Synthetic biology aims to design or assemble existing bioparts or bio-components for useful
bioproperties. During the past decades, progresses have been made to build delicate …

Optimization of biological networks is often limited by wet lab labor and cost, and the lack of
convenient computational tools. Here, we describe METIS, a versatile active machine …

Red light penetrates deep into mammalian tissues and has low phototoxicity, but few
optogenetic tools that use red light have been developed. Here we present MagRed, a red …

A fundamental challenge in synthetic biology is to create molecular circuits that can program
complex cellular functions. Because proteins can bind, cleave, and chemically modify one …

The ability of biological systems to tightly regulate targeted variables, despite external and
internal disturbances, is known as Robust Perfect Adaptation (RPA). Achieved frequently …

Chemically inducible systems represent valuable synthetic biology tools that enable the
external control of biological processes. However, their translation to therapeutic …

Cells rely on complex molecular networks to perceive and process external and internal
signals into tailored responses. These cellular abilities can be augmented and modified by …

Cell and gene therapies hold tremendous promise for treating a range of difficult-to-treat
diseases. However, concerns over the safety and efficacy require to be further addressed in …

There is a growing interest in the development of technologies to probe and direct in vitro
cellular function for fundamental organoid and stem cell biology, functional tissue and …