Overcoming negatively charged tissue barriers: Drug delivery using cationic peptides and proteins
Negatively charged tissues are ubiquitous in the human body and are associated with a
number of common diseases yet remain an outstanding challenge for targeted drug delivery …
number of common diseases yet remain an outstanding challenge for targeted drug delivery …
Materials for the spine: anatomy, problems, and solutions
Disc degeneration affects 12% to 35% of a given population, based on genetics, age,
gender, and other environmental factors, and usually occurs in the lumbar spine due to …
gender, and other environmental factors, and usually occurs in the lumbar spine due to …
Progress in electrospun composite nanofibers: composition, performance and applications for tissue engineering
The discovery of novel methods to fabricate optimal scaffolds that mimic both mechanical
and functional properties of the extracellular matrix (ECM) has always been the “holy grail” …
and functional properties of the extracellular matrix (ECM) has always been the “holy grail” …
Fucoidan-loaded nanofibrous scaffolds promote annulus fibrosus repair by ameliorating the inflammatory and oxidative microenvironments in degenerative …
Q Yu, F Han, Z Yuan, Z Zhu, C Liu, Z Tu, Q Guo… - Acta Biomaterialia, 2022 - Elsevier
Tissue engineering holds potential in the treatment of intervertebral disc degeneration (IDD).
However, implantation of tissue engineered constructs may cause foreign body reaction and …
However, implantation of tissue engineered constructs may cause foreign body reaction and …
Lessons learned from intervertebral disc pathophysiology to guide rational design of sequential delivery systems for therapeutic biological factors
Intervertebral disc (IVD) degeneration has been associated with low back pain, which is a
major musculoskeletal disorder and socio-economic problem that affects as many as 600 …
major musculoskeletal disorder and socio-economic problem that affects as many as 600 …
Strategies for annulus fibrosus regeneration: from biological therapies to tissue engineering
G Chu, C Shi, H Wang, W Zhang, H Yang… - … in bioengineering and …, 2018 - frontiersin.org
Intervertebral disc (IVD) is an avascular tissue which contributes to the weight bearing,
motion, and flexibility of spine. However, IVD is susceptible to damage and even failure due …
motion, and flexibility of spine. However, IVD is susceptible to damage and even failure due …
The effect of the fibre orientation of electrospun scaffolds on the matrix production of rabbit annulus fibrosus-derived stem cells
Annulus fibrosus (AF) tissue engineering has recently received increasing attention as a
treatment for intervertebral disc (IVD) degeneration; however, such engineering remains …
treatment for intervertebral disc (IVD) degeneration; however, such engineering remains …
[HTML][HTML] Proper animal experimental designs for preclinical research of biomaterials for intervertebral disc regeneration
Y Peng, X Qing, H Shu, S Tian, W Yang… - Biomaterials …, 2021 - ncbi.nlm.nih.gov
Low back pain is a vital musculoskeletal disease that impairs life quality, leads to disability
and imposes heavy economic burden on the society, while it is greatly attributed to …
and imposes heavy economic burden on the society, while it is greatly attributed to …
Delivery systems for the treatment of degenerated intervertebral discs
SBG Blanquer, DW Grijpma, AA Poot - Advanced drug delivery reviews, 2015 - Elsevier
The intervertebral disc (IVD) is the most avascular and acellular tissue in the body and
therefore prone to degeneration. During IVD degeneration, the balance between anabolic …
therefore prone to degeneration. During IVD degeneration, the balance between anabolic …
The role of microenvironment in stem cell-based regeneration of intervertebral disc
G Chu, W Zhang, F Han, K Li, C Liu, Q Wei… - … in Bioengineering and …, 2022 - frontiersin.org
Regenerative medicine for intervertebral disc (IVD) disease, by utilizing chondrocytes, IVD
cells, and stem cells, has progressed to clinical trials in the treatment of back pain, and has …
cells, and stem cells, has progressed to clinical trials in the treatment of back pain, and has …