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The nuclear-to-cytoplasmic ratio: coupling DNA content to cell size, cell cycle, and biosynthetic capacity
Though cell size varies between different cells and across species, the nuclear-to-
cytoplasmic (N/C) ratio is largely maintained across species and within cell types. A cell …
cytoplasmic (N/C) ratio is largely maintained across species and within cell types. A cell …
When bigger is better: the role of polyploidy in organogenesis
TL Orr-Weaver - Trends in Genetics, 2015 - cell.com
Defining how organ size is regulated, a process controlled not only by the number of cells
but also by the size of the cells, is a frontier in developmental biology. Large cells are …
but also by the size of the cells, is a frontier in developmental biology. Large cells are …
Genetic instability from a single S phase after whole-genome duplication
Diploid and stable karyotypes are associated with health and fitness in animals. By contrast,
whole-genome duplications—doublings of the entire complement of chromosomes—are …
whole-genome duplications—doublings of the entire complement of chromosomes—are …
[HTML][HTML] Myocardial polyploidization creates a barrier to heart regeneration in zebrafish
Correlative evidence suggests that polyploidization of heart muscle, which occurs naturally
in post-natal mammals, creates a barrier to heart regeneration. Here, we move beyond a …
in post-natal mammals, creates a barrier to heart regeneration. Here, we move beyond a …
Endoreplication and polyploidy: insights into development and disease
Polyploid cells have genomes that contain multiples of the typical diploid chromosome
number and are found in many different organisms. Studies in a variety of animal and plant …
number and are found in many different organisms. Studies in a variety of animal and plant …
Polyploidy in tissue homeostasis and regeneration
Polyploid cells, which contain multiple copies of the typically diploid genome, are
widespread in plants and animals. Polyploidization can be developmentally programmed or …
widespread in plants and animals. Polyploidization can be developmentally programmed or …
Dynamic blastomere behaviour reflects human embryo ploidy by the four-cell stage
Previous studies have demonstrated that aneuploidy in human embryos is surprisingly
frequent with 50–80% of cleavage-stage human embryos carrying an abnormal …
frequent with 50–80% of cleavage-stage human embryos carrying an abnormal …
The expanding implications of polyploidy
Polyploid cells, which contain more than two genome copies, occur throughout nature.
Beyond well-established roles in increasing cell size/metabolic output, polyploidy can also …
Beyond well-established roles in increasing cell size/metabolic output, polyploidy can also …
Drosophila melanogaster: a model and a tool to investigate malignancy and identify new therapeutics
For decades, lower-model organisms such as Drosophila melanogaster have often provided
the first glimpse into the mechanism of action of human cancer-related proteins, thus making …
the first glimpse into the mechanism of action of human cancer-related proteins, thus making …
Endoreplication: the good, the bad, and the ugly
To battle adverse internal and external conditions and maintain homeostasis, diploid
organisms employ various cellular processes, such as proliferation and apoptosis. In some …
organisms employ various cellular processes, such as proliferation and apoptosis. In some …