Physical stability of dry powder inhaler formulations
ABSTRACT Introduction: Dry powder inhalers (DPIs) are popular for pulmonary drug
delivery. Various techniques have been employed to produce inhalation drug particles and …
delivery. Various techniques have been employed to produce inhalation drug particles and …
Leucine as an excipient in spray dried powder for inhalation
Leucine is a promising excipient with several applications in the development of inhalable
spray-dried powder of high-and low-dose drugs. The addition of leucine has exhibited …
spray-dried powder of high-and low-dose drugs. The addition of leucine has exhibited …
[HTML][HTML] Designing enhanced spray dried particles for inhalation: A review of the impact of excipients and processing parameters on particle properties
Spray drying is a constructive single-step manufacturing technique used to produce dry
powder. Spray drying plays a remarkable role in producing inhalable powder formulations …
powder. Spray drying plays a remarkable role in producing inhalable powder formulations …
Influence of composition and spray-drying process parameters on carrier-free DPI properties and behaviors in the lung: A review
A Lechanteur, B Evrard - Pharmaceutics, 2020 - mdpi.com
Although dry powder inhalers (DPIs) have attracted great interest compared to nebulizers
and metered-dose inhalers (MDIs), drug deposition in the deep lung is still insufficient to …
and metered-dose inhalers (MDIs), drug deposition in the deep lung is still insufficient to …
Aerosol pulmonary immune engineering
ER Sudduth, M Trautmann-Rodriguez, N Gill… - Advanced Drug Delivery …, 2023 - Elsevier
Aerosolization of immunotherapies poses incredible potential for manipulating the local
mucosal-specific microenvironment, engaging specialized pulmonary cellular defenders …
mucosal-specific microenvironment, engaging specialized pulmonary cellular defenders …
Strategies for further stabilization of lipid-based delivery systems with a focus on solidification by spray-drying
Background Today, lipid-based delivery systems (LBDS: emulsions, nanostructured lipid
carriers, solid lipid nanoparticles, lipid-polymer hybrid nanoparticles, and nanoliposomes) …
carriers, solid lipid nanoparticles, lipid-polymer hybrid nanoparticles, and nanoliposomes) …
A critical review of spray-dried amorphous pharmaceuticals: synthesis, analysis and application
B Wang, F Liu, J **ang, Y He, Z Zhang, Z Cheng… - International Journal of …, 2021 - Elsevier
New drugs are frequently found with poor water-solubility in recent pharmaceutical projects,
which brings difficulties of bioavailability for the clinical development of new drugs. When …
which brings difficulties of bioavailability for the clinical development of new drugs. When …
Inhalable liposomal powder formulations for co-delivery of synergistic ciprofloxacin and colistin against multi-drug resistant gram-negative lung infections
The aim of this study was to design and characterize dry powder inhaler formulations of
ciprofloxacin and colistin co-loaded liposomes prepared by the ultrasonic spray-freeze …
ciprofloxacin and colistin co-loaded liposomes prepared by the ultrasonic spray-freeze …
Inhalable dry powder product (DPP) of mRNA lipid nanoparticles (LNPs) for pulmonary delivery
A Sarode, P Patel, N Vargas-Montoya, A Allawzi… - Drug Delivery and …, 2024 - Springer
Pulmonary delivery of mRNA via inhalation is a very attractive approach for RNA-based
therapy for treatment of lung diseases. In this work, we have demonstrated successful …
therapy for treatment of lung diseases. In this work, we have demonstrated successful …
Novel drug delivery systems and significance in respiratory diseases
Pulmonary drug delivery offers targeted therapy for the treatment of respiratory diseases
such as asthma, lung cancer, and chronic obstructive pulmonary diseases. However, this …
such as asthma, lung cancer, and chronic obstructive pulmonary diseases. However, this …