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Preconditioning is hormesis part I: Documentation, dose-response features and mechanistic foundations
EJ Calabrese - Pharmacological Research, 2016 - Elsevier
This article provides the first extensive documentation of the dose response features of pre-
and postconditioning. Pre-and postconditioning studies with rigorous study designs, using …
and postconditioning. Pre-and postconditioning studies with rigorous study designs, using …
The myocardial JAK/STAT pathway: from protection to failure
K Boengler, D Hilfiker-Kleiner, H Drexler… - Pharmacology & …, 2008 - Elsevier
Proteins of the interleukin-6 (IL-6) family bind to receptors in the plasma membrane.
Subsequent signal transduction involves activation of the janus kinase (JAK) and signal …
Subsequent signal transduction involves activation of the janus kinase (JAK) and signal …
Loss of cardioprotection with ageing
Not only the prevalence, but also the mortality due to ischaemic cardiovascular disease is
higher in older than in young humans, and the demographic shift towards an ageing …
higher in older than in young humans, and the demographic shift towards an ageing …
The non‐haematopoietic biological effects of erythropoietin
MO Arcasoy - British journal of haematology, 2008 - Wiley Online Library
In the haematopoietic system, the principal function of erythropoietin (Epo) is the regulation
of red blood cell production, mediated by its specific cell surface receptor (EpoR). Following …
of red blood cell production, mediated by its specific cell surface receptor (EpoR). Following …
Erythropoietin, erythropoiesis and beyond
Erythropoietin (EPO) is a glycoprotein that is mainly produced in the adult kidney, and it was
initially highlighted for its action on the hematopoietic system. Moreover, EPO is also …
initially highlighted for its action on the hematopoietic system. Moreover, EPO is also …
Protective effects of erythropoietin in cardiac ischemia: from bench to bedside
Erythropoietin (EPO) is a hypoxia-induced hormone produced in the kidneys that stimulates
hematopoiesis in the bone marrow. However, recent studies have also shown important …
hematopoiesis in the bone marrow. However, recent studies have also shown important …
Erythropoietin suppresses the hepatic fibrosis caused by thioacetamide: role of the PI3K/Akt and TLR4 signaling pathways
Erythropoietin (EPO) is recognized for its function in erythropoiesis; however, its potential
antifibrotic effect against liver fibrosis remains unknown. This study examined whether EPO …
antifibrotic effect against liver fibrosis remains unknown. This study examined whether EPO …
Timing of erythropoietin treatment for cardioprotection in ischemia/reperfusion
E Lipšic, P van der Meer, RH Henning… - Journal of …, 2004 - journals.lww.com
Erythropoietin (EPO) is a hormone known to stimulate hematopoiesis. However, recent
research suggests additional properties of EPO, such as protection against …
research suggests additional properties of EPO, such as protection against …
Erythropoietin protects cardiomyocytes from apoptosis via up-regulation of endothelial nitric oxide synthase
D Burger, M Lei, N Geoghegan-Morphet… - Cardiovascular …, 2006 - academic.oup.com
Abstract Objective: Erythropoietin (EPO), a cytokine best known for its ability to increase red
blood cell mass, has recently been shown to protect cardiomyocytes from apoptotic cell …
blood cell mass, has recently been shown to protect cardiomyocytes from apoptotic cell …
Erythropoietin in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: a randomized, double-blind …
I Ott, S Schulz, J Mehilli, S Fichtner… - Circulation …, 2010 - ahajournals.org
Background—Erythropoietin improves myocardial function in experimental models of
myocardial infarction. The aim of the present study was to determine the value of …
myocardial infarction. The aim of the present study was to determine the value of …