The 5′ m7G cap is an evolutionarily conserved modification of eukaryotic mRNA. Decades
of research have established that the m7G cap serves as a unique molecular module that …

Proper regulation of mRNA production in the nucleus is critical for the maintenance of
cellular homoeostasis during adaptation to internal and environmental cues. Over the past …

Numerous long intervening noncoding RNAs (lincRNAs) are generated from the mammalian
genome by RNA polymerase II (Pol II) transcription. Although multiple functions have been …

Transcription termination occurs when the polymerase is released after a transcription event,
thus delimitating transcription units; however, the functional importance of termination …

Argonaute proteins of the PIWI clade are central to transposon silencing in animal gonads.
Their target specificity is defined by 23–30 nt PIWI interacting RNAs (piRNAs), which mostly …

The RNA-binding ARS2 protein is centrally involved in both early RNA polymerase II
(RNAPII) transcription termination and transcript decay. Despite its essential nature, the …

The transcriptional termination of unstable non-coding RNAs (ncRNAs) is poorly understood
compared to coding transcripts. We recently identified ZC3H4-WDR82 (" restrictor") as …

The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate
targeting is facilitated by its co-factor Mtr4p/hMTR4, which links to RNA-binding protein …

Transcribing RNA Polymerase II interacts with multiple factors that orchestrate maturation
and stabilisation of messenger RNA. For the majority of noncoding RNAs, the polymerase …

The eukaryotic RNA exosome is an essential and conserved protein complex that can
degrade or process RNA substrates in the 3′-to-5′ direction. Since its discovery nearly …