Addiction is driven by excessive goal-directed drug choice under negative affect: translational critique of habit and compulsion theory
L Hogarth - Neuropsychopharmacology, 2020 - nature.com
Drug addiction may be a goal-directed choice driven by excessive drug value in negative
affective states, a habit driven by strong stimulus− response associations, or a compulsion …
affective states, a habit driven by strong stimulus− response associations, or a compulsion …
Dopamine prediction errors in reward learning and addiction: from theory to neural circuitry
Midbrain dopamine (DA) neurons are proposed to signal reward prediction error (RPE), a
fundamental parameter in associative learning models. This RPE hypothesis provides a …
fundamental parameter in associative learning models. This RPE hypothesis provides a …
Why is obesity such a problem in the 21st century? The intersection of palatable food, cues and reward pathways, stress, and cognition
Abstract Changes in food composition and availability have contributed to the dramatic
increase in obesity over the past 30–40 years in developed and, increasingly, in develo** …
increase in obesity over the past 30–40 years in developed and, increasingly, in develo** …
[HTML][HTML] Appetitive Pavlovian-instrumental transfer: a review
Reward-related cues are an important part of our daily life as they often influence and guide
our actions. This paper reviews one of the experimental paradigms used to study the effects …
our actions. This paper reviews one of the experimental paradigms used to study the effects …
Differential dopamine release dynamics in the nucleus accumbens core and shell reveal complementary signals for error prediction and incentive motivation
MP Saddoris, F Cacciapaglia… - Journal of …, 2015 - Soc Neuroscience
Mesolimbic dopamine (DA) is phasically released during appetitive behaviors, though there
is substantive disagreement about the specific purpose of these DA signals. For example …
is substantive disagreement about the specific purpose of these DA signals. For example …
Going and stop**: dichotomies in behavioral control by the prefrontal cortex
SL Gourley, JR Taylor - Nature neuroscience, 2016 - nature.com
The rodent dorsal medial prefrontal cortex (PFC), specifically the prelimbic cortex (PL),
regulates the expression of conditioned fear and behaviors interpreted as reward seeking …
regulates the expression of conditioned fear and behaviors interpreted as reward seeking …
Habit, choice, and addiction
Y Vandaele, SH Ahmed - Neuropsychopharmacology, 2021 - nature.com
Addiction was suggested to emerge from the progressive dominance of habits over goal-
directed behaviors. However, it is generally assumed that habits do not persist in choice …
directed behaviors. However, it is generally assumed that habits do not persist in choice …
P avlovian‐to‐instrumental transfer effects in the nucleus accumbens relate to relapse in alcohol dependence
In detoxified alcohol‐dependent patients, alcohol‐related stimuli can promote relapse.
However, to date, the mechanisms by which contextual stimuli promote relapse have not …
However, to date, the mechanisms by which contextual stimuli promote relapse have not …
Memory systems and the addicted brain
J Goodman, MG Packard - Frontiers in psychiatry, 2016 - frontiersin.org
The view that anatomically distinct memory systems differentially contribute to the
development of drug addiction and relapse has received extensive support. The present …
development of drug addiction and relapse has received extensive support. The present …
Nucleus accumbens core dopamine signaling tracks the need‐based motivational value of food‐paired cues
TJ Aitken, VY Greenfield… - Journal of …, 2016 - Wiley Online Library
Environmental reward‐predictive stimuli provide a major source of motivation for
instrumental reward‐seeking activity and this has been linked to dopamine signaling in the …
instrumental reward‐seeking activity and this has been linked to dopamine signaling in the …