Enhanced prime editing systems by manipulating cellular determinants of editing outcomes
While prime editing enables precise sequence changes in DNA, cellular determinants of
prime editing remain poorly understood. Using pooled CRISPRi screens, we discovered that …
prime editing remain poorly understood. Using pooled CRISPRi screens, we discovered that …
Mismatch repair
The concept of mismatch repair (MMR) was formulated independently in 1964 to explain the
removal of brominated nucleotides from DNA as well as gene conversion during genetic …
removal of brominated nucleotides from DNA as well as gene conversion during genetic …
Lynch syndrome, molecular mechanisms and variant classification
Patients with the heritable cancer disease, Lynch syndrome, carry germline variants in the
MLH1, MSH2, MSH6 and PMS2 genes, encoding the central components of the DNA …
MLH1, MSH2, MSH6 and PMS2 genes, encoding the central components of the DNA …
ELM—the eukaryotic linear motif resource in 2020
M Kumar, M Gouw, S Michael… - Nucleic acids …, 2020 - academic.oup.com
Studies on the DNA-binding properties of transcription factors are important in searching for
the downstream genes regulated by these factors. In the present study, we report on the …
the downstream genes regulated by these factors. In the present study, we report on the …
Exonuclease 1-dependent and independent mismatch repair
EM Goellner, CD Putnam, RD Kolodner - DNA repair, 2015 - Elsevier
DNA mismatch repair (MMR) acts to repair mispaired bases resulting from misincorporation
errors during DNA replication and also recognizes mispaired bases in recombination (HR) …
errors during DNA replication and also recognizes mispaired bases in recombination (HR) …
New insights into the mechanism of DNA mismatch repair
GX Reyes, TT Schmidt, RD Kolodner, H Hombauer - Chromosoma, 2015 - Springer
The genome of all organisms is constantly being challenged by endogenous and
exogenous sources of DNA damage. Errors like base: base mismatches or small insertions …
exogenous sources of DNA damage. Errors like base: base mismatches or small insertions …
[HTML][HTML] Strand discrimination in DNA mismatch repair
CD Putnam - DNA repair, 2021 - Elsevier
DNA mismatch repair (MMR) corrects non-Watson-Crick basepairs generated by replication
errors, recombination intermediates, and some forms of chemical damage to DNA. In MutS …
errors, recombination intermediates, and some forms of chemical damage to DNA. In MutS …
Mlh1-Mlh3, a meiotic crossover and DNA mismatch repair factor, is a Msh2-Msh3-stimulated endonuclease
Crossing over between homologous chromosomes is initiated in meiotic prophase in most
sexually reproducing organisms by the appearance of programmed double strand breaks …
sexually reproducing organisms by the appearance of programmed double strand breaks …
Roles for mismatch repair family proteins in promoting meiotic crossing over
CM Manhart, E Alani - DNA repair, 2016 - Elsevier
The mismatch repair (MMR) family complexes Msh4-Msh5 and Mlh1-Mlh3 act with Exo1 and
Sgs1-Top3-Rmi1 in a meiotic double strand break repair pathway that results in the …
Sgs1-Top3-Rmi1 in a meiotic double strand break repair pathway that results in the …
The Saccharomyces cerevisiae Mlh1-Mlh3 heterodimer is an endonuclease that preferentially binds to Holliday junctions
MutLγ, a heterodimer of the MutL homologues Mlh1 and Mlh3, plays a critical role during
meiotic homologous recombination. The meiotic function of Mlh3 is fully dependent on the …
meiotic homologous recombination. The meiotic function of Mlh3 is fully dependent on the …