Aging is driven by hallmarks fulfilling the following three premises:(1) their age-associated
manifestation,(2) the acceleration of aging by experimentally accentuating them, and (3) the …

Both aging and cancer are characterized by a series of partially overlap**" hallmarks" that
we subject here to a meta-analysis. Several hallmarks of aging (ie, genomic instability …

Caloric restriction and intermittent fasting prolong the lifespan and healthspan of model
organisms and improve human health. The natural polyamine spermidine has been similarly …

Normal circulatory function is a key determinant of disease-free life expectancy (healthspan).
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …

Aims Sodium-glucose co-transporter 2 (SGLT2) inhibitors improve cardiovascular outcomes
in diverse patient populations, but their mechanism of action requires further study. The aim …

Cardiac aging is evident by a reduction in function which subsequently contributes to heart
failure. The metabolic microenvironment has been identified as a hallmark of malignancy …

In an aging society, unveiling new anti-aging strategies to prevent and combat aging-related
diseases is of utmost importance. Mitochondria are the primary ATP production sites and key …

Aims Growth differentiation factor‐15 (GDF‐15) is upregulated in part in response to
cardiomyocyte stretch and stress, and it exerts a protective role that is mediated by its action …

Background The renin‐angiotensin system plays a crucial role in the development of heart
failure, and Ang II (angiotensin II) acts as the critical effector of the renin‐angiotensin system …

Aging is widespread worldwide and a significant risk factor for cardiovascular disease
(CVD). Mechanisms underlying aging have attracted considerable attention in recent years …