Ion channels in the heart

DC Bartos, E Grandi… - Comprehensive …, 2015‏ - pmc.ncbi.nlm.nih.gov
Optimal cardiac function depends on proper timing of excitation and contraction in various
regions of the heart, as well as on appropriate heart rate. This is accomplished via …

Genesis and regulation of the heart automaticity

ME Mangoni, J Nargeot - Physiological reviews, 2008‏ - journals.physiology.org
The heart automaticity is a fundamental physiological function in higher organisms. The
spontaneous activity is initiated by specialized populations of cardiac cells generating …

Transcriptomic profiling of the develo** cardiac conduction system at single-cell resolution

WR Goodyer, BM Beyersdorf, DT Paik, L Tian… - Circulation …, 2019‏ - ahajournals.org
Rationale: The cardiac conduction system (CCS) consists of distinct components including
the sinoatrial node, atrioventricular node, His bundle, bundle branches, and Purkinje fibers …

Molecular architecture of the human sinus node: insights into the function of the cardiac pacemaker

NJ Chandler, ID Greener, JO Tellez, S Inada, H Musa… - Circulation, 2009‏ - ahajournals.org
Background—Although we know much about the molecular makeup of the sinus node (SN)
in small mammals, little is known about it in humans. The aims of the present study were to …

New insights into pacemaker activity: promoting understanding of sick sinus syndrome

H Dobrzynski, MR Boyett, RH Anderson - Circulation, 2007‏ - ahajournals.org
artery (Figure 2B), although the relationship to the artery varies from individual to individual.
8 The nodal cells are set in a matrix of fibrous tissue, with a relatively discrete boundary …

Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene Hcn4

M Baruscotti, A Bucchi, C Viscomi, G Mandelli… - Proceedings of the …, 2011‏ - pnas.org
Cardiac pacemaking generation and modulation rely on the coordinated activity of several
processes. Although a wealth of evidence indicates a relevant role of the If (“funny,” or …

Development of the pacemaker tissues of the heart

VM Christoffels, GJ Smits, A Kispert… - Circulation …, 2010‏ - ahajournals.org
Pacemaker and conduction system myocytes play crucial roles in initiating and regulating
the contraction of the cardiac chambers. Genetic defects, acquired diseases, and aging …

Structure, function and clinical relevance of the cardiac conduction system, including the atrioventricular ring and outflow tract tissues

H Dobrzynski, RH Anderson, A Atkinson… - Pharmacology & …, 2013‏ - Elsevier
It is now over 100years since the discovery of the cardiac conduction system, consisting of
three main parts, the sinus node, the atrioventricular node and the His–Purkinje system. The …

The anatomy and physiology of the sinoatrial node—a contemporary review

O Monfredi, H Dobrzynski, T Mondal… - Pacing and clinical …, 2010‏ - Wiley Online Library
The sinoatrial node is the primary pacemaker of the heart. Nodal dysfunction with aging,
heart failure, atrial fibrillation, and even endurance athletic training can lead to a wide variety …

Exploring HCN channels as novel drug targets

O Postea, M Biel - Nature reviews Drug discovery, 2011‏ - nature.com
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels have a key role in the
control of heart rate and neuronal excitability. Ivabradine is the first compound acting on …