Phase reduction and phase-based optimal control for biological systems: a tutorial

B Monga, D Wilson, T Matchen, J Moehlis - Biological cybernetics, 2019 - Springer
A powerful technique for the analysis of nonlinear oscillators is the rigorous reduction to
phase models, with a single variable describing the phase of the oscillation with respect to …

Control and synchronization of neuron ensembles

JS Li, I Dasanayake, J Ruths - IEEE Transactions on automatic …, 2013 - ieeexplore.ieee.org
Synchronization of oscillations is a phenomenon prevalent in natural, social, and
engineering systems. Controlling synchronization of oscillating systems is motivated by a …

Optimal chaotic desynchronization for neural populations

D Wilson, J Moehlis - SIAM Journal on Applied Dynamical …, 2014 - search.proquest.com
A procedure is developed for finding an energy-optimal stimulus which gives a positive
Lyapunov exponent, and hence desynchronization, for a neural population. The procedure …

Minimum energy desynchronizing control for coupled neurons

A Nabi, M Mirzadeh, F Gibou, J Moehlis - Journal of computational …, 2013 - Springer
We employ optimal control theory to design an event-based, minimum energy,
desynchronizing control stimulus for a network of pathologically synchronized …

Single input optimal control for globally coupled neuron networks

A Nabi, J Moehlis - Journal of neural engineering, 2011 - iopscience.iop.org
We consider the problem of desynchronizing a network of synchronized, globally (all-to-all)
coupled neurons using an input to a single neuron. This is done by applying the discrete …

Stochastic optimal control of single neuron spike trains

A Iolov, S Ditlevsen, A Longtin - Journal of neural engineering, 2014 - iopscience.iop.org
Objective. External control of spike times in single neurons can reveal important information
about a neuron's sub-threshold dynamics that lead to spiking, and has the potential to …

Minimum energy control for in vitro neurons

A Nabi, T Stigen, J Moehlis… - Journal of neural …, 2013 - iopscience.iop.org
Objective. To demonstrate the applicability of optimal control theory for designing minimum
energy charge-balanced input waveforms for single periodically-firing in vitro neurons from …

Time optimal control of spiking neurons

A Nabi, J Moehlis - Journal of mathematical biology, 2012 - Springer
By injecting an electrical current control stimulus into a neuron, one can change its inter-
spike intervals. In this paper, we investigate the time optimal control problem for periodically …

Locally optimal extracellular stimulation for chaotic desynchronization of neural populations

D Wilson, J Moehlis - Journal of computational neuroscience, 2014 - Springer
We use optimal control theory to design a methodology to find locally optimal stimuli for
desynchronization of a model of neurons with extracellular stimulation. This methodology …

Constrained charge-balanced minimum-power controls for spiking neuron oscillators

IS Dasanayake, JS Li - Systems & Control Letters, 2015 - Elsevier
In this paper, we study the optimal control of phase models for spiking neuron oscillators. We
focus on the design of minimum-power current stimuli that elicit spikes of neurons at …