Since the first pioneering studies on small deuterated peptides dating more than 20 years
ago, 1H detection has evolved into the most efficient approach for investigation of …

Solid-state NMR with magic-angle spinning (MAS) is an important method in structural
biology. While NMR can provide invaluable information about local geometry on an atomic …

Solid-state NMR spectroscopy (ssNMR) with magic-angle spinning (MAS) enables the
investigation of biological systems within their native context, such as lipid membranes, viral …

Proton detection developed in the last 20 years as the method of choice to study
biomolecules in the solid state. In perdeuterated proteins, proton dipolar interactions are …

The drug Rimantadine binds to two different sites in the M2 protein from influenza A, a
peripheral site and a pore site that is the primary site of efficacy. It remained enigmatic that …

The NMR signals from protein sidechains are rich in information about intra-and inter-
molecular interactions, but their detection can be complicated due to spectral overlap as well …

Ion channels are ubiquitous throughout all forms of life. Potassium channels are even found
in viruses. Every cell must communicate with its surroundings, so all cells have them, and …

With an estimated 1 billion people affected across the globe, influenza is one of the most
serious health concerns worldwide. Therapeutic treatments have encompassed a number of …

Little is known about how maturation of Alzheimer's disease-related amyloid β (Aβ) fibrils
alters their stability and potentially influences their spreading in the brain. Using high …

Influenza A virus (IAV) poses a serious threat to human life and property. The IAV matrix
protein 2 (M2) is significant in viral budding. Increasing studies have proven the important …