The role of cell-mediated immunity in bacterial infections

H Hahn, SHE Kaufmann - Reviews of infectious diseases, 1981 - JSTOR
Reactions of tissues to infection by nontoxigenic bacteria may be conveniently divided into
two forms: purulent and granulomatous. Purulent infections, as exemplified by …

The regulatory role of macrophages in antigenic stimulation part two: Symbiotic relationship between lymphocytes and macrophages

ER Unanue - Advances in immunology, 1981 - Elsevier
Publisher Summary Changes in antigen molecules that resulted in enhanced or decreased
uptake by the phagocytes resulted in higher or lower immune responses, respectively. After …

T-cell mitogens cause early changes in cytoplasmic free Ca2+ and membrane potential in lymphocytes

RY Tsien, T Pozzan, TJ Rink - Nature, 1982 - nature.com
One of the best models for studying the control of mammalian cell growth and proliferation is
the response of lymphocytes to mitogenic agents1–4, which stimulate growth, DNA …

IL-21 enhances and sustains CD8+ T cell responses to achieve durable tumor immunity: comparative evaluation of IL-2, IL-15, and IL-21

A Moroz, C Eppolito, Q Li, J Tao, CH Clegg… - The Journal of …, 2004 - journals.aai.org
Cytokines that use the common receptor γ-chain for regulating CD8+ T cell responses to Ag
include IL-2, IL-15, and the recently identified IL-21. The ability of these cytokines to regulate …

Cyclosporin A mediates immunosuppression of primary cytotoxic T cell responses by impairing the release of interleukin 1 and interleukin 2

D Bunjes, C Hardt, M Röllinghoff… - European journal of …, 1981 - Wiley Online Library
The site of action of the immunosuppressive drug cyclosporin A in in vitro cytotoxic allograft
responses has been localized. General cytotoxic effects of the drug on proliferating T cells …

Eradication of disseminated murine leukemia by chemoimmunotherapy with cyclophosphamide and adoptively transferred immune syngeneic Lyt-1+ 2-lymphocytes.

PD Greenberg, MA Cheever, A Fefer - The Journal of experimental …, 1981 - rupress.org
The phenotype of T cells therapeutically effective in immunotherapy of advanced Friend
virus-induced (FBL) leukemia in vivo and cytotoxic to FBL in vitro was determined. Mice …

Augmentation of the anti-tumor therapeutic efficacy of long-term cultured T lymphocytes by in vivo administration of purified interleukin 2.

MA Cheever, PD Greenberg, A Fefer… - The Journal of …, 1982 - rupress.org
Spleen cells from C57BL/6 mice immunized in vivo with a syngeneic Friend virus-induced
leukemia, FBL-3, were specifically activated by culture for 7 d with FBL-3, then …

Role of CD40 ligand and CD28 in induction and maintenance of antiviral CD8+ effector T cell responses

SØ Andreasen, JE Christensen, O Marker… - The Journal of …, 2000 - journals.aai.org
The primary aim of this report was to evaluate the immune responses of CD40 ligand-
deficient (CD40L−/−) mice infected with two viruses known to differ markedly in their capacity …

Leflunomide (HWA 486), a novel immunomodulating compound for the treatment of autoimmune disorders and reactions leading to transplantation rejection

RR Bartlett, M Dimitrijevic, T Mattar, T Zielinski… - Agents and actions, 1991 - Springer
Leflunomide has been shown to be very effective in preventing and curing several
autoimmune animal diseases. Further, this agent is as effective as cyclosporin A in …

Lectin receptors as lymphocyte surface markers

N Sharon - Advances in immunology, 1983 - Elsevier
Publisher Summary The lectin receptors are characteristic markers of distinct lymphocyte
subpopulations in mouse, man, and several other animals. Just like antigenic surface …