Membrane and nuclear estrogen receptor alpha actions: from tissue specificity to medical implications
JF Arnal, F Lenfant, R Metivier, G Flouriot… - Physiological …, 2017 - journals.physiology.org
Estrogen receptor alpha (ERα) has been recognized now for several decades as playing a
key role in reproduction and exerting functions in numerous nonreproductive tissues. In this …
key role in reproduction and exerting functions in numerous nonreproductive tissues. In this …
International union of basic and clinical pharmacology CXIII: Nuclear receptor superfamily—Update 2023
The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …
gene network programs involved in a wide range of physiologic processes. This review will …
Chromatin interaction analysis reveals changes in small chromosome and telomere clustering between epithelial and breast cancer cells
Background Higher-order chromatin structure is often perturbed in cancer and other
pathological states. Although several genetic and epigenetic differences have been charted …
pathological states. Although several genetic and epigenetic differences have been charted …
Real-time imaging of a single gene reveals transcription-initiated local confinement
Genome dynamics are intimately linked to the regulation of gene expression, the most
fundamental mechanism in biology, yet we still do not know whether the very process of …
fundamental mechanism in biology, yet we still do not know whether the very process of …
Long-range gene regulation in hormone-dependent cancer
The human genome is organized into multiple structural layers, ranging from chromosome
territories to progressively smaller substructures, such as topologically associating domains …
territories to progressively smaller substructures, such as topologically associating domains …
Androgen and androgen receptor as enhancers of M2 macrophage polarization in allergic lung inflammation
M Becerra-Díaz, AB Strickland, A Keselman… - The Journal of …, 2018 - journals.aai.org
Allergic asthma is a disease initiated by a breach of the lung mucosal barrier and an
inappropriate Th2 inflammatory immune response that results in M2 polarization of alveolar …
inappropriate Th2 inflammatory immune response that results in M2 polarization of alveolar …
Pre-established chromatin interactions mediate the genomic response to glucocorticoids
The glucocorticoid receptor (GR) is a hormone-inducible transcription factor involved in
metabolic and anti-inflammatory gene expression responses. To investigate what controls …
metabolic and anti-inflammatory gene expression responses. To investigate what controls …
Estradiol-induced epigenetically mediated mechanisms and regulation of gene expression
Gonadal hormone 17β-estradiol (E2) and its receptors are key regulators of gene
transcription by binding to estrogen responsive elements in the genome. Besides the …
transcription by binding to estrogen responsive elements in the genome. Besides the …
Genome-wide estrogen receptor activity in breast cancer
AM Farcas, S Nagarajan, S Cosulich, JS Carroll - Endocrinology, 2021 - academic.oup.com
The largest subtype of breast cancer is characterized by the expression and activity of the
estrogen receptor alpha (ERalpha/ER). Although several effective therapies have …
estrogen receptor alpha (ERalpha/ER). Although several effective therapies have …
Signaling by steroid hormones in the 3D nuclear space
Initial studies showed that ligand-activated hormone receptors act by binding to the proximal
promoters of individual target genes. Genome-wide studies have now revealed that …
promoters of individual target genes. Genome-wide studies have now revealed that …