The current state of serum biomarkers of hepatotoxicity
J Ozer, M Ratner, M Shaw, W Bailey, S Schomaker - Toxicology, 2008 - Elsevier
The level of serum alanine aminotransferase (ALT) activity reflects damage to hepatocytes
and is considered to be a highly sensitive and fairly specific preclinical and clinical …
and is considered to be a highly sensitive and fairly specific preclinical and clinical …
Modulation of paraoxonase (PON1) activity
LG Costa, A Vitalone, TB Cole, CE Furlong - Biochemical pharmacology, 2005 - Elsevier
Paraoxonase 1 (PON1) is a serum enzyme closely associated with high density lipoprotein
(HDL). PON1 hydrolyzes several organophosphorus compounds used as insecticides, as …
(HDL). PON1 hydrolyzes several organophosphorus compounds used as insecticides, as …
Human paraoxonase-1 (PON1): Gene structure and expression, promiscuous activities and multiple physiological roles
M Mackness, B Mackness - Gene, 2015 - Elsevier
Human PON1 is a HDL-associated lipolactonase capable of preventing LDL and cell
membrane oxidation and is therefore considered to be atheroprotective. PON1 contributes to …
membrane oxidation and is therefore considered to be atheroprotective. PON1 contributes to …
Enzymes involved in the bioconversion of ester-based prodrugs
BM Liederer, RT Borchardt - Journal of pharmaceutical sciences, 2006 - Elsevier
Enzymes are essential for the activation of many prodrugs. In this review, the most important
enzymes (eg, paraoxonase, carboxylesterase, acetylcholinesterase, cholinesterase) …
enzymes (eg, paraoxonase, carboxylesterase, acetylcholinesterase, cholinesterase) …
[HTML][HTML] Antioxidant and anti-inflammatory role of paraoxonase 1: implication in arteriosclerosis diseases
D Litvinov, H Mahini, M Garelnabi - North American journal of …, 2012 - ncbi.nlm.nih.gov
Abstract Paraoxonase 1 (PON1) is a hydrolytic enzyme with wide range of substrates, and
capability to protect against lipid oxidation. Despite of the large number of compounds that …
capability to protect against lipid oxidation. Despite of the large number of compounds that …
Diazinon-induced hepatotoxicity and protective effect of vitamin E on some biochemical indices and ultrastructural changes
Diazinon, an organophosphate insecticide has been used in agriculture and domestic for
several years. The aim of present study was to analyze the hepatotoxic effect of diazinon …
several years. The aim of present study was to analyze the hepatotoxic effect of diazinon …
Paraoxonase and atherosclerosis-related cardiovascular diseases
DA Chistiakov, AA Melnichenko, AN Orekhov… - Biochimie, 2017 - Elsevier
In humans, three paraoxonase (PON1, PON2, and PON3) genes are clustered on
chromosome 7 at a locus that spans a distance around 170 kb. These genes are highly …
chromosome 7 at a locus that spans a distance around 170 kb. These genes are highly …
The paraoxonases: role in human diseases and methodological difficulties in measurement
Research into the paraoxonase (PON) gene family has flourished over the past few years. In
the 1970s and 1980s, only PON1 was known, and the investigations were conducted …
the 1970s and 1980s, only PON1 was known, and the investigations were conducted …
Paraoxonase gene polymorphisms, oxidative stress, and diseases
HL Li, DP Liu, CC Liang - Journal of molecular medicine, 2003 - Springer
The paraoxonase (PON) gene cluster contains at least three members, including PON1,
PON2, and PON3, located on chromosome 7q21. 3–22.1. Until now there has been little …
PON2, and PON3, located on chromosome 7q21. 3–22.1. Until now there has been little …
Biomarkers of liver diseases
SS Tamber, P Bansal, S Sharma, RB Singh… - Molecular Biology …, 2023 - Springer
The liver is one of the pivotal organs in the human body and is fundamentally responsible for
detoxification and metabolism. Various disorders such as non-alcoholic fatty liver disease …
detoxification and metabolism. Various disorders such as non-alcoholic fatty liver disease …