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Neuroinflammation in cerebral ischemia and ischemia/reperfusion injuries: from pathophysiology to therapeutic strategies
Its increasing incidence has led stroke to be the second leading cause of death worldwide.
Despite significant advances in recanalization strategies, patients are still at risk for …
Despite significant advances in recanalization strategies, patients are still at risk for …
Immune cells in the BBB disruption after acute ischemic stroke: targets for immune therapy?
Y Qiu, C Zhang, A Chen, H Wang, Y Zhou… - Frontiers in …, 2021 - frontiersin.org
Blood-Brain Barrier (BBB) disruption is an important pathophysiological process of acute
ischemic stroke (AIS), resulting in devastating malignant brain edema and hemorrhagic …
ischemic stroke (AIS), resulting in devastating malignant brain edema and hemorrhagic …
Neutrophils as emerging therapeutic targets
Neutrophils are the most abundant circulating leukocytes, being the first line of defence
against bacterial and fungal infections. However, neutrophils also contribute to tissue …
against bacterial and fungal infections. However, neutrophils also contribute to tissue …
Hemorrhagic transformation in ischemic stroke and the role of inflammation
Hemorrhagic transformation (HT) is a common complication in patients with acute ischemic
stroke. It occurs when peripheral blood extravasates across a disrupted blood brain barrier …
stroke. It occurs when peripheral blood extravasates across a disrupted blood brain barrier …
Neuroimmune mechanisms and therapies mediating post-ischaemic brain injury and repair
The nervous and immune systems control whole-body homeostasis and respond to various
types of tissue injury, including stroke, in a coordinated manner. Cerebral ischaemia and …
types of tissue injury, including stroke, in a coordinated manner. Cerebral ischaemia and …
Neutrophils in acute inflammation: current concepts and translational implications
Modulation of neutrophil recruitment and function is crucial for targeting inflammatory cells to
sites of infection to combat invading pathogens while, at the same time, limiting host tissue …
sites of infection to combat invading pathogens while, at the same time, limiting host tissue …
Development of novel therapeutics targeting the blood–brain barrier: from barrier to carrier
The blood–brain barrier (BBB) is a highly specialized neurovascular unit, initially described
as an intact barrier to prevent toxins, pathogens, and potentially harmful substances from …
as an intact barrier to prevent toxins, pathogens, and potentially harmful substances from …
Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American …
Background and Purpose—The authors present an overview of the current evidence and
management recommendations for evaluation and treatment of adults with acute ischemic …
management recommendations for evaluation and treatment of adults with acute ischemic …
Integrin-based therapeutics: biological basis, clinical use and new drugs
Integrins are activatable molecules that are involved in adhesion and signalling. Of the 24
known human integrins, 3 are currently targeted therapeutically by monoclonal antibodies …
known human integrins, 3 are currently targeted therapeutically by monoclonal antibodies …
Innate immunity in diabetes and diabetic nephropathy
J Wada, H Makino - Nature Reviews Nephrology, 2016 - nature.com
The innate immune system includes several classes of pattern recognition receptors (PRRs),
including membrane-bound Toll-like receptors (TLRs) and nucleotide-binding …
including membrane-bound Toll-like receptors (TLRs) and nucleotide-binding …