[HTML][HTML] Role of miRNA-regulated cancer stem cells in the pathogenesis of human malignancies

AQ Khan, EI Ahmed, NR Elareer, K Junejo, M Steinhoff… - Cells, 2019 - mdpi.com
Recent biomedical discoveries have revolutionized the concept and understanding of
carcinogenesis, a complex and multistep phenomenon which involves accretion of genetic …

Cancer-associated miRNAs and their therapeutic potential

J Inoue, J Inazawa - Journal of human genetics, 2021 - nature.com
MicroRNA (miRNA; miR) is a functionally small non-coding RNA and can negatively
regulate gene expression by directly binding to the target gene. Some miRNAs are closely …

[HTML][HTML] Regulatory mechanisms of epigenetic miRNA relationships in human cancer and potential as therapeutic targets

KMT Arif, EK Elliott, LM Haupt, LR Griffiths - Cancers, 2020 - mdpi.com
Simple Summary By the virtue of targeting multiple genes, a microRNA (miRNA) can infer
variable consequences on tumorigenesis by appearing as both a tumour suppressor and …

[HTML][HTML] Friend or foe: S100 proteins in cancer

C Allgöwer, AL Kretz, S von Karstedt, M Wittau… - Cancers, 2020 - mdpi.com
S100 proteins are widely expressed small molecular EF-hand calcium-binding proteins of
vertebrates, which are involved in numerous cellular processes, such as Ca2+ homeostasis …

[HTML][HTML] MicroRNAs and their big therapeutic impacts: delivery strategies for cancer intervention

C Holjencin, A Jakymiw - Cells, 2022 - mdpi.com
Three decades have passed from the initial discovery of a microRNA (miRNA) in
Caenorhabditis elegans to our current understanding that miRNAs play essential roles in …

Hsa_circ_0002483 inhibited the progression and enhanced the Taxol sensitivity of non-small cell lung cancer by targeting miR-182-5p

X Li, B Yang, H Ren, T **ao, L Zhang, L Li, M Li… - Cell death & …, 2019 - nature.com
In this study, we identified a novel circRNA, circ_0002483, and further investigated its
functions in the progression and Taxol resistance of NSCLC. We found that circ_0002483 …

Use of microRNAs as diagnostic, prognostic, and therapeutic tools for glioblastoma

D Valle-Garcia, V Pérez de la Cruz, I Flores… - International Journal of …, 2024 - mdpi.com
Glioblastoma (GB) is the most aggressive and common type of cancer within the central
nervous system (CNS). Despite the vast knowledge of its physiopathology and histology, its …

The current state of MiRNAs as biomarkers and therapeutic tools

I Gareev, O Beylerli, G Yang, J Sun, V Pavlov… - Clinical and …, 2020 - Springer
MicroRNAs (miRNAs) are non-coding RNAs with a length of 18–22 nucleotides that regulate
about a third of the human genome at the post-transcriptional level. MiRNAs are involved in …

[HTML][HTML] miRacle of microRNA-driven cancer nanotherapeutics

G Kara, B Arun, GA Calin, B Ozpolat - Cancers, 2022 - mdpi.com
Simple Summary The discovery of microRNAs has revolutionized the world of science and
opened up new opportunities in cancer treatment. miRNA dysregulation plays a crucial role …

Sensitivity and specificity of microRNA-204, CA125, and CA19. 9 as biomarkers for diagnosis of ovarian cancer

FT Ali, RM Soliman, NS Hassan, AM Ibrahim… - PLoS …, 2022 - journals.plos.org
Background Ovarian cancer is usually detected at later stages and no effective screening
approach, has been identified. Therefore, sensitive and specific biomarkers for detecting …