Circular RNA in cancer

VM Conn, AM Chinnaiyan, SJ Conn - Nature Reviews Cancer, 2024 - nature.com
Over the past decade, circular RNA (circRNA) research has evolved into a bona fide
research field shedding light on the functional consequence of this unique family of RNA …

Role of circular RNAs in disease progression and diagnosis of cancers: An overview of recent advanced insights

SU Khan, MU Khan, MI Khan, AA Fadahunsi… - International journal of …, 2022 - Elsevier
Tumor microenvironment (TME) is a crucial regulator of tumor progression and cells in the
TME release a number of molecules that are responsible for anaplasticity, invasion …

circAtlas 3.0: a gateway to 3 million curated vertebrate circular RNAs based on a standardized nomenclature scheme

W Wu, F Zhao, J Zhang - Nucleic Acids Research, 2024 - academic.oup.com
Recent studies have demonstrated the important regulatory role of circRNAs, but an in-depth
understanding of the comprehensive landscape of circRNAs across various species still …

Full-length circular RNA profiling by nanopore sequencing with CIRI-long

L Hou, J Zhang, F Zhao - Nature Protocols, 2023 - nature.com
Circular RNAs (circRNAs) have important roles in regulating developmental processes and
disease progression. As most circRNA sequences are highly similar to their cognate linear …

Circular RNAs in the human brain are tailored to neuron identity and neuropsychiatric disease

X Dong, Y Bai, Z Liao, D Gritsch, X Liu, T Wang… - Nature …, 2023 - nature.com
Little is known about circular RNAs (circRNAs) in specific brain cells and human
neuropsychiatric disease. Here, we systematically identify over 11,039 circRNAs expressed …

Current advances in circular RNA detection and investigation methods: Are we running in circles?

R Drula, C Braicu… - Wiley Interdisciplinary …, 2024 - Wiley Online Library
Circular RNAs (circRNAs), characterized by their closed‐loop structure, have emerged as
significant transcriptomic regulators, with roles spanning from microRNA sponging to …

Optimal design of synthetic circular RNAs

SW Choi, JW Nam - Experimental & Molecular Medicine, 2024 - nature.com
Circular RNAs are an unusual class of single-stranded RNAs whose ends are covalently
linked via back-splicing. Due to their versatility, the need to express circular RNAs in vivo …

Approaches and challenges in genome-wide circular RNA identification and quantification

XK Ma, SN Zhai, L Yang - Trends in Genetics, 2023 - cell.com
Numerous circular RNAs (circRNAs) produced from back-splicing of exon (s) have been
recently revealed on a genome-wide scale across species. Although generally expressed at …

Exosomal circ-PTPN22 and circ-ADAMTS6 mark T cell exhaustion and neutrophil extracellular traps in Asian intrahepatic cholangiocarcinoma

X Wang, G Wang, Z Wu, Y Dong, Y Shi, F Yang… - … Therapy-Nucleic Acids, 2023 - cell.com
Intrahepatic cholangiocarcinoma (ICC) is a liver tumor featured by challenges of non-
invasive early diagnosis and a higher prevalence rate in Asian countries. These …

CircRNAs: versatile players and new targets in organ fibrosis

L Wei, L Liu, M Bai, X Ning, S Sun - Cell Communication and Signaling, 2023 - Springer
Organ fibrosis can occur in virtually all major organs with relentlessly progressive and
irreversible progress, ultimately resulting in organ dysfunction and potentially death …