The heterogeneity of tissue macrophages, in health and in disease, has become
increasingly transparent over the last decade. But with the plethora of data comes a natural …

Tissue-resident alveolar and interstitial macrophages and recruited macrophages are critical
players in innate immunity and maintenance of lung homeostasis. Until recently, assessing …

Some patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
develop severe pneumonia and acute respiratory distress syndrome (ARDS). Distinct …

COVID-19 is a contagious viral disease caused by SARS-CoV-2 that led to an ongoing
pandemic with massive global health and socioeconomic consequences. The disease is …

Pneumonia and its sequelae, acute lung injury, present unique challenges for pulmonary
and critical care healthcare professionals, and these challenges have recently garnered …

Lung macrophages play important roles in the maintenance of homeostasis, pathogen
clearance and immune regulation. The different types of pulmonary macrophages and their …

Alveolar macrophages (AMs) are the sentinel cells of the alveolar space, maintaining
homeostasis, fending off pathogens, and controlling lung inflammation. During acute lung …

Aside from centrally induced trained immunity in the bone marrow (BM) and peripheral
blood by parenteral vaccination or infection, evidence indicates that mucosal-resident innate …

INTRODUCTION The collective behavior of cells and insects often relies on self-organizing
processes. By releasing attractant signals, a few individuals can initiate the accumulation …

Kupffer cells (KCs) are localized in liver sinusoids but extend pseudopods to parenchymal
cells to maintain their identity and serve as the body's central bacterial filter. Liver cirrhosis …