Recently, screens for mediators of resistance to FLT3 and ABL kinase inhibitors in leukemia
resulted in the discovery of LZTR1 as an adapter of a Cullin-3 RING E3 ubiquitin ligase …

RIT1 is a RAS guanosine triphosphatase (GTPase) that regulates different aspects of signal
transduction and is mutated in lung cancer, leukemia, and in the germline of individuals with …

Noonan syndrome patients harboring causative variants in LZTR1 are particularly at risk to
develop severe and early-onset hypertrophic cardiomyopathy. In this study, we investigate …

RASopathies, a group of neurodevelopmental congenital disorders stemming from
mutations in the RAS/MAPK pathway, present a unique opportunity to delve into the …

Gene variants in LZTR1 are implicated to cause Noonan syndrome associated with a severe
and early-onset hypertrophic cardiomyopathy. Mechanistically, LZTR1 deficiency results in …

Meningomyelocele is one of the most severe forms of neural tube defects (NTDs) and the
most frequent structural birth defect of the central nervous system. We assembled the Spina …

Leucine-zipper–like posttranslational regulator 1 (LZTR1) is a member of the BTB-Kelch
superfamily, which regulates the RAS proteostasis. Autosomal dominant (AD) mutations in …

Human SCs play a primary role in SWN, a rare genetic disorder in which patients develop
multiple schwannomas. So that, their isolation and immortalization could represent an …

Understanding the molecular mechanisms that underlie different human pathologies is
necessary to develop novel therapeutic strategies. An emerging mechanism of …

In the budding yeast Saccharomyces cerevisiae, exit from mitosis is coupled to spindle
position to ensure successful genome partitioning between mother and daughter cell. This …