Coadjuvants in the diabetic complications: nutraceuticals and drugs with pleiotropic effects
TMC Pereira, FS Pimenta, ML Porto, MP Baldo… - International Journal of …, 2016 - mdpi.com
Because diabetes mellitus (DM) is a multifactorial metabolic disease, its prevention and
treatment has been a constant challenge for basic and clinical investigators focused on …
treatment has been a constant challenge for basic and clinical investigators focused on …
The role of cGMP and its signaling pathways in kidney disease
K Shen, DW Johnson, GC Gobe - American Journal of …, 2016 - journals.physiology.org
Cyclic nucleotide signal transduction pathways are an emerging research field in kidney
disease. Activated cell surface receptors transduce their signals via intracellular second …
disease. Activated cell surface receptors transduce their signals via intracellular second …
Chronic administration of the probiotic kefir improves the endothelial function in spontaneously hypertensive rats
AGF Friques, CM Arpini, IC Kalil, AL Gava… - Journal of Translational …, 2015 - Springer
Background The beverage obtained by fermentation of milk with kefir grains, a complex
matrix containing acid bacteria and yeasts, has been shown to have beneficial effects in …
matrix containing acid bacteria and yeasts, has been shown to have beneficial effects in …
Increased ROS production and DNA damage in monocytes are biomarkers of aging and atherosclerosis
TA Jacinto, GS Meireles, AT Dias, R Aires, ML Porto… - Biological research, 2018 - Springer
Background New evidence demonstrates that aging and dyslipidemia are closely
associated with oxidative stress, DNA damage and apoptosis in some cells and …
associated with oxidative stress, DNA damage and apoptosis in some cells and …
Chronic administration of the soluble, nonbacterial fraction of kefir attenuates lipid deposition in LDLr−/− mice
AF Santanna, PF Filete, EM Lima, ML Porto… - Nutrition, 2017 - Elsevier
Objectives Kefir is obtained by the action of acidic bacteria and yeasts that exist in symbiotic
association in kefir grains. Recently, this fermented milk drink has been recommended for …
association in kefir grains. Recently, this fermented milk drink has been recommended for …
Bisphenol A contamination in infant rats: Molecular, structural, and physiological cardiovascular changes and the protective role of kefir
AGF Friques, FDN Santos, DB Angeli, FAC Silva… - The Journal of …, 2020 - Elsevier
The effects of bisphenol A (BPA) contamination on the cardiovascular function still are not
clear. Here, we evaluated the vascular effects of BPA and the protective actions of kefir in …
clear. Here, we evaluated the vascular effects of BPA and the protective actions of kefir in …
Oxidative stress and inflammatory profiles in obstructive sleep apnea: are short-term CPAP or aerobic exercise therapies effective?
YG Borges, LHC Cipriano, R Aires, PVC Zovico… - Sleep and …, 2020 - Springer
Purpose The effects of medium to long-term continuous positive airway pressure (CPAP) or
physical activity in decreasing oxidative stress, inflammatory, and cell-free DNA markers in …
physical activity in decreasing oxidative stress, inflammatory, and cell-free DNA markers in …
The phosphodiesterase type 5 inhibitor sildenafil improves dna stability and redox homeostasis in systemic sclerosis fibroblasts exposed to reactive oxygen species
L Di Luigi, G Duranti, A Antonioni, P Sgrò, R Ceci… - Antioxidants, 2020 - mdpi.com
Systemic sclerosis (SSc) is a multi-system connective tissue disease characterized by the
increased deposition of extracellular matrix proteins such as collagen and fibronectin …
increased deposition of extracellular matrix proteins such as collagen and fibronectin …
Novel Therapeutic Targets for Phosphodiesterase 5 Inhibitors: current state-of-the-art on systemic arterial hypertension and atherosclerosis
EC Vasquez, AL Gava, JB Graceli… - Current …, 2016 - ingentaconnect.com
The usefulness of selective inhibitors of phosphodiesterase 5 (PDE5) is well known, first for
the treatment of male erectile dysfunction and more recently for pulmonary hypertension …
the treatment of male erectile dysfunction and more recently for pulmonary hypertension …
Sildenafil prevents renal dysfunction in contrast media-induced nephropathy in Wistar rats
LS Almeida, JR Barboza, FPS Freitas… - Human & …, 2016 - journals.sagepub.com
Contrast-induced nephropathy (CIN) is an iatrogenic medical event in stable cardiology
patients that may lead to acute renal failure. There is no current successful therapy to …
patients that may lead to acute renal failure. There is no current successful therapy to …