[HTML][HTML] Emerging mechanisms and dynamics of three-dimensional genome organisation at zygotic genome activation
The genome of an early embryo undergoes significant remodelling at the epigenetic,
transcriptional, and structural levels. New technological developments have made it …
transcriptional, and structural levels. New technological developments have made it …
Pioneering the developmental frontier
ED Larson, AJ Marsh, MM Harrison - Molecular cell, 2021 - cell.com
Coordinated changes in gene expression allow a single fertilized oocyte to develop into a
complex multi-cellular organism. These changes in expression are controlled by …
complex multi-cellular organism. These changes in expression are controlled by …
The DNA-to-cytoplasm ratio broadly activates zygotic gene expression in Xenopus
In multicellular animals, the first major event after fertilization is the switch from maternal to
zygotic control of development. During this transition, zygotic gene transcription is broadly …
zygotic control of development. During this transition, zygotic gene transcription is broadly …
Awakening of the zygotic genome by pioneer transcription factors
W Kobayashi, K Tachibana - Current Opinion in Structural Biology, 2021 - Elsevier
After fertilization, the genome of the totipotent embryo is transcriptionally inactive and then
initiates bursts of transcription termed zygotic genome activation (ZGA). Despite the …
initiates bursts of transcription termed zygotic genome activation (ZGA). Despite the …
Control of zygotic genome activation in Xenopus
IL Blitz, KWY Cho - Current topics in developmental biology, 2021 - Elsevier
The fertilized frog egg contains all the materials needed to initiate development of a new
organism, including stored RNAs and proteins deposited during oogenesis, thus the earliest …
organism, including stored RNAs and proteins deposited during oogenesis, thus the earliest …
Pluripotency factors determine gene expression repertoire at zygotic genome activation
M Gao, M Veil, M Rosenblatt, AJ Riesle… - Nature …, 2022 - nature.com
Awakening of zygotic transcription in animal embryos relies on maternal pioneer
transcription factors. The interplay of global and specific functions of these proteins remains …
transcription factors. The interplay of global and specific functions of these proteins remains …
Pou5f3 and Sox19b select gene expression repertoire at Zygotic Genome Activation
PouV and SoxB1 family transcription factors (TFs) have emerged as master regulators of cell
fate transitions. To investigate the genetic interactions between Pou5f3 and Sox19b in …
fate transitions. To investigate the genetic interactions between Pou5f3 and Sox19b in …
The miR-430 locus with extreme promoter density is a transcription body organizer, which facilitates long range regulation in zygotic genome activation
Y Hadzhiev, L Wheatley, L Cooper, F Ansaloni… - BioRxiv, 2021 - biorxiv.org
In anamniote embryos the major wave of zygotic genome activation (ZGA) starts during the
mid-blastula transition. This major wave of ZGA is facilitated by several mechanisms …
mid-blastula transition. This major wave of ZGA is facilitated by several mechanisms …
The effect of Activin pathway modulation on the expression of both pluripotency and differentiation markers during early zebrafish development compared with other …
Activin‐like factors control many developmental processes, including pluripotency
maintenance and differentiation. Although Activin‐like factors' action in mesendoderm …
maintenance and differentiation. Although Activin‐like factors' action in mesendoderm …
Maternal and zygotic activin signaling promotes adequate pattern and differentiation of mesoderm through regulation of pluripotency genes during zebrafish …
To investigate the role of maternal Activin-like factors in the preservation of stemness and
mesendoderm induction, their effects were promoted and inhibited using synthetic human …
mesendoderm induction, their effects were promoted and inhibited using synthetic human …