Recent advances in cholinergic mechanisms as reactions to toxicity, stress, and neuroimmune insults

Z Kovarik, G Moshitzky, N Maček Hrvat… - Journal of …, 2024 - Wiley Online Library
This review presents recent studies of the chemical and molecular regulators of
acetylcholine (ACh) signaling and the complexity of the small molecule and RNA regulators …

Sex‐specific declines in cholinergic‐targeting tRNA fragments in the nucleus accumbens in Alzheimer's disease

D Shulman, S Dubnov, T Zorbaz… - Alzheimer's & …, 2023 - Wiley Online Library
Abstract Introduction Females with Alzheimer's disease (AD) suffer accelerated dementia
and loss of cholinergic neurons compared to males, but the underlying mechanisms are …

Knockout of the longevity gene Klotho perturbs aging and Alzheimer's disease-linked brain microRNAs and tRNA fragments

S Dubnov, ER Bennett, N Yayon, O Yakov… - Communications …, 2024 - nature.com
Overexpression of the longevity gene Klotho prolongs lifespan, while its knockout shortens
lifespan and impairs cognition via perturbation of myelination and synapse formation …

Sex-Specific Impact of Fkbp5 on Hippocampal Response to Acute Alcohol Injection: Involvement in Alterations of Metabolism-Related Pathways

KE Williams, Y Zou, B Qiu, T Kono, C Guo, D Garcia… - Cells, 2023 - mdpi.com
High levels of alcohol intake alter brain gene expression and can produce long-lasting
effects. FK506-binding protein 51 (FKBP51) encoded by Fkbp5 is a physical and cellular …

[HTML][HTML] Molecular states underlying neuronal cell type development and plasticity in the whisker cortex

S Butrus, HR Monday, CJ Yoo, DE Feldman… - …, 2024 - pmc.ncbi.nlm.nih.gov
Mouse whisker somatosensory cortex (wS1) is a major model system to study the
experience-dependent plasticity of cortical neuron physiology, morphology, and sensory …

Effect of ferric citrate on hippocampal iron accumulation and widespread molecular alterations associated with cognitive disorder in an ovariectomized mice model

L Cui, H Zhou, Y Hao, X Yang, Z Li… - CNS Neuroscience …, 2024 - Wiley Online Library
Objective Nowadays, the prevalence of cognitive impairment in women has gradually
increased, especially in postmenopausal women. There were few studies on the …

Spinal cord injury regulates circular RNA expression in axons

MM Siddiq, CA Toro, NP Johnson, J Hansen… - Frontiers in Molecular …, 2023 - frontiersin.org
Introduction Neurons transport mRNA and translational machinery to axons for local
translation. After spinal cord injury (SCI), de novo translation is assumed to enable …

[PDF][PDF] Acknowledgements: The authors would like to thank Dr. Soheila Karimi at the University of Manitoba, Winnipeg, Canada for assistance with oligodendrocyte …

MM Siddiq - researchgate.net
After spinal cord injury (SCI), de novo translation is assumed to enable neurorepair.
Knowledge of the identity of axonal mRNAs that participate in neurorepair after SCI is …