Ferroptosis is an iron-dependent cell death, which is different from apoptosis, necrosis,
autophagy, and other forms of cell death. The process of ferroptotic cell death is defined by …

Selenium (Se) is a naturally occurring metalloid element essential to human and animal
health in trace amounts but it is harmful in excess. Se plays a substantial role in the …

Abstract Glutathione peroxidase 4 (GPX4) utilizes glutathione (GSH) to detoxify lipid
peroxidation and plays an essential role in inhibiting ferroptosis. As a selenoprotein, GPX4 …

Selenoproteins are rare proteins among all kingdoms of life containing the 21 st amino acid,
selenocysteine. Selenocysteine resembles cysteine, differing only by the substitution of …

An appropriate control over cell cycle progression depends on many factors. Cyclin-
dependent kinase (CDK) inhibitor p21 (also known as p21 WAF1/Cip1) is one of these …

Arsenic, cadmium, lead, and mercury are toxic elements that are almost ubiquitously present
at low levels in the environment because of anthropogenic influences. Dietary intake of plant …

Reactive oxygen species (ROS) are frequently produced during viral infections. Generation
of these ROS can be both beneficial and detrimental for many cellular functions. When …

Cd is the third major contaminant of greatest hazard to the environment after mercury and
lead and is considered as the only metal that poses health risks to both humans and animals …

Selenium (Se) is an essential micronutrient for humans and animals, but lead to toxicity
when taken in excessive amounts. Plants are the main source of dietary Se, but essentiality …

Here, we addressed the pharmacology and toxicology of synthetic organoselenium
compounds and some naturally occurring organoselenium amino acids. The use of …