It is estimated that nearly a third of people who abuse drugs started with prescription opioid
medicines. Approximately, 11.5 million Americans used prescription drugs recreationally in …

Limited evidence has suggested that terpenes found in Cannabis sativa are analgesic, and
could produce an “entourage effect” whereby they modulate cannabinoids to result in …

As our understanding of diseases deepens, increasing therapeutic targets are being
identified, which facilitates the development of new drug candidates. However, drug …

We conducted a narrative review of the literature to compare the pharmacological, efficacy
and safety profiles of tapentadol and tramadol, and to assess the clinical interest of …

The only medication available currently to prevent and treat opioid overdose (naloxone) was
approved by the US Food and Drug Administration (FDA) nearly 50 years ago. Because of …

Several neurochemical systems converge in the prefrontal cortex (PFC) to regulate cognitive
and motivated behaviors. A rich network of endogenous opioid peptides and receptors …

Compared to traditional experimental approaches, computational modeling is a promising
strategy to efficiently prioritize new candidates with low cost. In this study, we developed a …

Akuammicine (1), an alkaloid isolated from Picralima nitida, is an agonist of the kappa opioid
receptor (κOR). To establish structure–activity relationships (SARs) for this structurally …

Opioid agonist ligands bind opioid receptors and stimulate downstream signaling cascades
for various biological processes including pain and reward. Historically, before cloning the …

The opioid receptors are important regulators of pain, reward, and addiction. Limited
evidence suggests the mu and delta opioid receptors form a heterodimer (MDOR), which …