Circular RNAs as biomarkers and therapeutic targets in cancer

A Beilerli, I Gareev, O Beylerli, G Yang, V Pavlov… - Seminars in cancer …, 2022 - Elsevier
Circular RNAs (circRNAs) are a class of single-stranded closed non-coding RNA molecules
(ncRNAs), which are formed as a result of reverse splicing of mRNAs. Despite their relative …

[HTML][HTML] Epigenetic programing of cancer stemness by transcription factors-non-coding RNAs interactions

RKME Alsayed, KSAM Sheikhan, MA Alam… - Seminars in cancer …, 2023 - Elsevier
Cancer 'stemness' is fundamental to cancer existence. It defines the ability of cancer cells to
indefinitely perpetuate as well as differentiate. Cancer stem cell populations within a …

Non‐coding RNA involvement in the pathogenesis of diabetic cardiomyopathy

W Zhang, W Xu, Y Feng, X Zhou - Journal of Cellular and …, 2019 - Wiley Online Library
In recent years, the incidence of diabetes has been increasing rapidly, which seriously
endangers human health. Diabetic cardiomyopathy, an important cardiovascular …

Noncoding RNAs in hypertension

A Jusic, Y Devaux… - …, 2019 - ahajournals.org
High blood pressure or hypertension is an outstanding public health problem affecting
nearly 40% of the World's adult population. Prevalence of hypertension has a strong …

A novel circRNA-miRNA-mRNA network identifies circ-YOD1 as a biomarker for coronary artery disease

L Miao, RX Yin, QH Zhang, PJ Liao, Y Wang, RJ Nie… - Scientific Reports, 2019 - nature.com
Circular RNAs (circRNAs) are involved in many physiological functions. Whether circulating
circRNAs serve as markers for coronary artery disease (CAD) is unknown. Seven CAD …

Involvement of circHIPK3 in the pathogenesis of diabetic cardiomyopathy in mice

W Wang, S Zhang, L Xu, Y Feng, X Wu, M Zhang, Z Yu… - Diabetologia, 2021 - Springer
Aims/hypothesis In a mouse model of diabetic cardiomyopathy (DCM) the expression of the
circular RNA circHIPK3 was found to be significantly increased. This study aimed to discover …

Comprehensive analysis of circular RNAs in pathological states: biogenesis, cellular regulation, and therapeutic relevance

C Braicu, AA Zimta, D Gulei, A Olariu… - Cellular and molecular …, 2019 - Springer
Circular RNAs (circRNAs) are members of the non-coding transcriptome; however, some of
them are translated into proteins. These transcripts have important roles in both …

Increased circulating circular RNA_103516 is a novel biomarker for inflammatory bowel disease in adult patients

YL Ye, J Yin, T Hu, LP Zhang, LY Wu… - World journal of …, 2019 - pmc.ncbi.nlm.nih.gov
BACKGROUND Increasing evidence demonstrates that by acting as microRNA sponges
modulating gene expression at the transcriptional or post-transcriptional level, circular RNAs …

Circular RNA RBPMS inhibits bladder cancer progression via miR-330-3p/RAI2 regulation

C Yang, Z Mou, Z Zhang, S Wu, Q Zhou, Y Chen… - … Therapy Nucleic Acids, 2021 - cell.com
Bladder cancer is a severe cancer with high mortality because of invasion and metastasis.
Growing evidence has revealed that circular RNAs play critical roles in biological function …

Circular RNAs and their roles in head and neck cancers

Y Guo, J Yang, Q Huang, C Hsueh, J Zheng, C Wu… - Molecular cancer, 2019 - Springer
Circular RNAs are abundant endogenous non-coding RNA with no 5′ cap and 3′
polyadenylation tail that modify liner mRNAs and have no terminal structures. Our …