Adaptation is fundamental to life. All organisms adapt over timescales that span from
evolution to generations and lifetimes to moment-by-moment interactions. The nervous …

Quantifying similarity and dissimilarity of spike trains is an important requisite for
understanding neural codes. Spike metrics constitute a class of approaches to this problem …

We present the mathematical basis of a new approach to the analysis of temporal coding.
The foundation of the approach is the construction of several families of novel distances …

Cortical synapses exhibit several forms of short-term plasticity, but the contribution of this
plasticity to visual response dynamics is unknown. In part, this is because the simple …

We explore the effects of short-term synaptic depression on the temporal dynamics of V1
responses to visual images by constructing a model simple cell. Synaptic depression is …

A" brain defibrillator" may be closer than we think. An epileptic seizure involves a
paroxysmal change in the activity of millions of neurons. Feedback control of seizures would …

We present an approach to estimate information carried by experimentally observed neural
spike trains elicited by known stimuli. This approach makes use of an embedding of the …

1 EPSCs were recorded under whole‐cell voltage clamp at room temperature from Purkinje
cells in slices of cerebellum from 12‐to 14‐day‐old rats. EPSCs from individual climbing …

We have studied the synaptic responses in hippocampal slices to stimulus patterns derived
from in vivo recordings of place cell firing in a behaving rodent. We find that synaptic …

Neuromodulation by peptides and amines is a primary source of plasticity in the nervous
system as it adapts the animal to an ever-changing environment. The crustacean …