Nonalcoholic fatty liver disease and hypercholesterolemia: roles of thyroid hormones, metabolites, and agonists
Background: Thyroid hormones (THs) exert a strong influence on mammalian lipid
metabolism at the systemic and hepatic levels by virtue of their roles in regulating circulating …
metabolism at the systemic and hepatic levels by virtue of their roles in regulating circulating …
Thyroid hormone transporters
S Groeneweg, FS van Geest, RP Peeters… - Endocrine …, 2020 - academic.oup.com
Thyroid hormone transporters at the plasma membrane govern intracellular bioavailability of
thyroid hormone. Monocarboxylate transporter (MCT) 8 and MCT10, organic anion …
thyroid hormone. Monocarboxylate transporter (MCT) 8 and MCT10, organic anion …
Guidelines for the treatment of hypothyroidism: prepared by the american thyroid association task force on thyroid hormone replacement
Background: A number of recent advances in our understanding of thyroid physiology may
shed light on why some patients feel unwell while taking levothyroxine monotherapy. The …
shed light on why some patients feel unwell while taking levothyroxine monotherapy. The …
Automatic identification of mobile and rigid substructures in molecular dynamics simulations and fractional structural fluctuation analysis
L Martínez - PloS one, 2015 - journals.plos.org
The analysis of structural mobility in molecular dynamics plays a key role in data
interpretation, particularly in the simulation of biomolecules. The most common mobility …
interpretation, particularly in the simulation of biomolecules. The most common mobility …
International union of basic and clinical pharmacology CXIII: Nuclear receptor superfamily—Update 2023
The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …
gene network programs involved in a wide range of physiologic processes. This review will …
Chemistry and biology in the biosynthesis and action of thyroid hormones
S Mondal, K Raja, U Schweizer… - Angewandte Chemie …, 2016 - Wiley Online Library
Thyroid hormones (THs) are secreted by the thyroid gland. They control lipid, carbohydrate,
and protein metabolism, heart rate, neural development, as well as cardiovascular, renal …
and protein metabolism, heart rate, neural development, as well as cardiovascular, renal …
American Thyroid Association guide to investigating thyroid hormone economy and action in rodent and cell models: report of the American Thyroid Association Task …
AC Bianco, G Anderson, D Forrest, VA Galton… - Thyroid, 2014 - liebertpub.com
Background: An in-depth understanding of the fundamental principles that regulate thyroid
hormone homeostasis is critical for the development of new diagnostic and treatment …
hormone homeostasis is critical for the development of new diagnostic and treatment …
Medium chain fatty acids are selective peroxisome proliferator activated receptor (PPAR) γ activators and pan-PPAR partial agonists
Thiazolidinediones (TZDs) act through peroxisome proliferator activated receptor (PPAR) γ
to increase insulin sensitivity in type 2 diabetes (T2DM), but deleterious effects of these …
to increase insulin sensitivity in type 2 diabetes (T2DM), but deleterious effects of these …
Orthogonal fluorescent chemogenetic reporters for multicolor imaging
AG Tebo, B Moeyaert, M Thauvin… - Nature chemical …, 2021 - nature.com
Spectrally separated fluorophores allow the observation of multiple targets simultaneously
inside living cells, leading to a deeper understanding of the molecular interplay that …
inside living cells, leading to a deeper understanding of the molecular interplay that …
Cell-free protein synthesis approach to biosensing hTRβ-specific endocrine disruptors
ASM Salehi, MJ Shakalli Tang, MT Smith… - Analytical …, 2017 - ACS Publications
Here we introduce a Rapid Adaptable Portable In vitro Detection biosensor platform (RAPID)
for detecting ligands that interact with nuclear hormone receptors (NHRs). The RAPID …
for detecting ligands that interact with nuclear hormone receptors (NHRs). The RAPID …